M
Maria Grazia Morgese
Researcher at University of Foggia
Publications - 68
Citations - 3449
Maria Grazia Morgese is an academic researcher from University of Foggia. The author has contributed to research in topics: Neurochemical & Internal medicine. The author has an hindex of 27, co-authored 61 publications receiving 2921 citations. Previous affiliations of Maria Grazia Morgese include University of Texas Health Science Center at San Antonio.
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Antidepressant-like activity and modulation of brain monoaminergic transmission by blockade of anandamide hydrolysis
Gabriella Gobbi,Francis Rodriguez Bambico,Regina A. Mangieri,Marco Bortolato,Patrizia Campolongo,Marcello Solinas,Tommaso Cassano,Maria Grazia Morgese,Guy Debonnel,Andrea Duranti,Andrea Tontini,Giorgio Tarzia,Marco Mor,Viviana Trezza,Steven R. Goldberg,Vincenzo Cuomo,Daniele Piomelli +16 more
TL;DR: It is shown that URB597, a selective inhibitor of the enzyme fatty-acid amide hydrolase, which catalyzes the intracellular hydrolysis of the endocannabinoid anandamide, exerts potent antidepressant-like effects in the mouse tail-suspension test and the rat forced-swim test.
Antidepressant-Like Activity and Modulation of Brain Monoaminergic Transmission by Blockade of Anandamide Hydrolysis
Gabriella Gobbi,Francis Rodriguez Bambico,Regina A. Mangieri,Marco Bortolato,Patrizia Campolongo,Tommaso Cassano,Maria Grazia Morgese,Guy Debonnel,Andrea Duranti,A. Tontini,Giorgio Tarzia,Marco Mor,Viviana Trezza,Steven R. Goldberg,Vincenzo Cuomo,Daniele Piomelli +15 more
TL;DR: Gobi et al. as discussed by the authors showed that URB597, a selective inhibitor of the enzyme fatty acid amide hydrolase, which catalyzes the intracellular hydrolysis of the endocannabinoid anandamide, exerts potent antidepressant-like effects in the mouse tail-suspension test and the rat forced-swim test.
Journal ArticleDOI
Anti-dyskinetic effects of cannabinoids in a rat model of Parkinson's disease: Role of CB1 and TRPV1 receptors
TL;DR: The data indicate that pharmacological blockade of TRPV1 receptors unmasks the anti-dyskinetic effects of FAAH inhibitors and that CB(1) and TRP V1 receptors play opposite roles in levodopa-induced dyskinesias.
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Nonmotor symptoms in Parkinson's disease: investigating early-phase onset of behavioral dysfunction in the 6-hydroxydopamine-lesioned rat model.
Igor Branchi,Ivana D'Andrea,Monica Armida,Tommaso Cassano,Antonella Pèzzola,Rosa Luisa Potenza,Maria Grazia Morgese,Patrizia Popoli,Enrico Alleva +8 more
TL;DR: Overall, the PD rat model used here displays behavioral alterations having face validity with psychiatric symptoms of the pathology and thus appears to be a valuable tool for investigating the neural bases of the early phases of PD.
Journal ArticleDOI
Neurobiological links between depression and AD: The role of TGF-β1 signaling as a new pharmacological target
Filippo Caraci,Simona Federica Spampinato,Maria Grazia Morgese,Fabio Tascedda,Maria Grazia Salluzzo,Maria Concetta Giambirtone,Giuseppe Caruso,Antonio Munafò,Sebastiano Alfio Torrisi,Gian Marco Leggio,Luigia Trabace,Ferdinando Nicoletti,Filippo Drago,Maria Angela Sortino,Agata Copani +14 more
TL;DR: The TGF‐&bgr;1 signaling pathway is proposed as a common pharmacological target in depression and AD, and the potential rescue of TGF-1 signaling by antidepressants as a way to prevent the transition from depression to AD is discussed.