R
Regina Nomizo
Publications - 7
Citations - 933
Regina Nomizo is an academic researcher. The author has contributed to research in topics: Astrocyte & Binding site. The author has an hindex of 7, co-authored 7 publications receiving 892 citations.
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Journal ArticleDOI
Stress-inducible protein 1 is a cell surface ligand for cellular prion that triggers neuroprotection
Silvio M. Zanata,Marilene H. Lopes,Adriana F. Mercadante,Glaucia N. M. Hajj,Luciana B. Chiarini,Regina Nomizo,Adriana Freitas,A. L. B. Cabral,Kil Sun Lee,Maria A. Juliano,Elizabeth de Oliveira,Saul G. Jachieri,Alma L. Burlingame,Lan Huang,Rafael Linden,Ricardo R. Brentani,Vilma R. Martins +16 more
TL;DR: Cell surface binding and pull‐down experiments showed that recombinant PrPc binds to cellular STI1, and co‐immunoprecipitation assays strongly suggest that both proteins are associated in vivo.
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PTX3 function as an opsonin for the dectin-1-dependent internalization of zymosan by macrophages
Susana Nogueira Diniz,Regina Nomizo,Patrícia Silva Cisalpino,Mauro M. Teixeira,Gordon D. Brown,Alberto Mantovani,Siamon Gordon,Luiz F. L. Reis,Adriana Abalen Martins Dias +8 more
TL;DR: Evidence is provided for a role of PTX3 as an important component of the innate‐immune response and as part of the host mechanisms that control fungal recognition and phagocytosis.
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Identification of enolase as a laminin-binding protein on the surface of Staphylococcus aureus.
Célia Regina Whitaker Carneiro,Edilberto Postol,Regina Nomizo,Luiz F. L. Reis,Ricardo R. Brentani +4 more
TL;DR: The cell surface localization of S. aureus alpha-enolase was further confirmed by flow cytometry, and it might play a critical role in the pathogenesis of the bacteria by allowing its adherence to laminin-containing extracellular matrix.
Journal ArticleDOI
Cellular prion protein expression in astrocytes modulates neuronal survival and differentiation.
Flavia Regina Souza Lima,Camila P. Arantes,Angelita G. Muras,Regina Nomizo,Ricardo R. Brentani,Vilma R. Martins +5 more
TL;DR: Data indicate that PrPC expression in astrocytes is critical for sustaining cell‐to‐cell interactions, the organization of the extracellular matrix, and the secretion of soluble factors, all of which are essential events for neuronal differentiation and survival.
Journal ArticleDOI
Prion protein and its ligand stress inducible protein 1 regulate astrocyte development.
Camila P. Arantes,Regina Nomizo,Marilene H. Lopes,Glaucia N. M. Hajj,Flavia Regina Souza Lima,Vilma R. Martins +5 more
TL;DR: The data show that PrPC and STI1 are essential to astrocyte development and act through distinct signaling pathways, andSTI1 inhibited proliferation of both wild‐type and PrPC‐nullAstrocytes in a protein kinase C‐dependent manner.