R
Regina Reszka
Researcher at Max Delbrück Center for Molecular Medicine
Publications - 100
Citations - 2949
Regina Reszka is an academic researcher from Max Delbrück Center for Molecular Medicine. The author has contributed to research in topics: Liposome & Transfection. The author has an hindex of 27, co-authored 100 publications receiving 2857 citations. Previous affiliations of Regina Reszka include Charité & University of Potsdam.
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Journal ArticleDOI
Positron-emission tomography of vector-mediated gene expression in gene therapy for gliomas.
Andreas H. Jacobs,Juergen Voges,Regina Reszka,Martin J. Lercher,Axel Gossmann,Lutz W. Kracht,Ch Kaestle,Rainer Wagner,Klaus Wienhard,W.-D. Heiss +9 more
TL;DR: The extent of HSV-1-tk gene expression seemed to predict the therapeutic response, and the expression of an exogenous gene introduced by gene therapy into patients with gliomas can be monitored non-invasively by PET.
Journal ArticleDOI
Imaging-guided convection-enhanced delivery and gene therapy of glioblastoma.
Juergen Voges,Regina Reszka,Axel Gossmann,Claus Dittmar,Raphaela Richter,Guido Garlip,Lutz W. Kracht,Heinz H. Coenen,Volker Sturm,Karl Wienhard,Wolf-Dieter Heiss,Andreas H. Jacobs +11 more
TL;DR: Visualization of therapeutic effects on tumor metabolism and documentation of gene expression using positron emission tomography indicated that molecular imaging technology appears to be essential for the further development of biological treatment strategies.
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Utilization of synthetic peptides containing nuclear localization signals for nonviral gene transfer systems.
Regis Cartier,Regina Reszka +1 more
TL;DR: This review critically summarize recent studies applying the synthetic peptides containing a nuclear localization signal (NLS) to DNA so that the resulting DNA–NLS complex can be recognized as a nuclear import substrate by specific intracellular receptor proteins.
Journal ArticleDOI
Competitive adsorption of serum proteins at microparticles affects phagocytosis by dendritic cells.
TL;DR: Significant inhibition of phagocytosis was observed, even when HSA was combined with strong opsonins such as alpha2GP or IgG or in mixtures of all three proteins, indicating the importance of studying the influence of protein adsorption in protein mixtures.
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Mitochondria as subcellular targets for clinically useful anthracyclines.
Katinka Jung,Regina Reszka +1 more
TL;DR: The wide spectrum of possible mode of actions of these antibiotics leading to mitochondrial dysfunctions will be presented and discussed and the corresponding underlying mechanisms need to be understood.