Reidar Albrechtsen

TL;DR: A novel, secreted form of human ADAM 12 (meltrin α), designatedADAM 12-S (S for short), and a larger, membrane-bound form designated ADam 12-L (L for long form) are described, which have potential applications in the development of muscle-directed gene and cell therapies.

TL;DR: The purification of full-length recombinant ADAM 12-S is described and it is demonstrated that it cleaves insulin-like growth factor binding protein-3 (IGFBP-3) and this result supports a role for ADAM 11-S in the degradation of IGF BP-3 in the blood of pregnant women.

TL;DR: The studies suggest that staining for laminin may be a useful adjunct test for detection of micrometatases in lymph nodes, and supports the notion that basement membranes may play a role in tumor invasion.

TL;DR: The data suggest that mesenchymal cells use syndecans as the initial receptor for the ADAM 12 cysteine-rich domain–mediated cell adhesion, and then the β1 integrin to induce cell spreading.

TL;DR: The level of laminin receptor mRNA in a variety of human carcinoma-derived cell lines correlated with the number of laminationin receptors on the cell surfaces of those cells, which suggests that the amount of laminate receptor mRNA may be a rate-limiting control step in the biosynthesis of the laminIn receptor, and hence in the regulation of cellular attachment to basement membranes via lamin in.