Reidun Torp

TL;DR: It is demonstrated that tau is cleaved at D421 (DeltaTau) by executioner caspases, and therapeutics aimed at inhibiting tau caspase-cleavage may prove beneficial not only in preventing NFT formation, but also in slowing cognitive decline.

TL;DR: The association of LRRK2 with a variety of membrane and vesicular structures, membrane-bound organelles, and microtubules suggests an affinity of L RRK2 for lipids or lipid-associated proteins and may suggest a potential role in the biogenesis and/or regulation of vesicle and membranous intracellular structures within the mammalian brain.

TL;DR: It is found that DJ-1 is widely distributed and is highly expressed in the brain and mitochondrial matrix and inter-membrane space and is an integral mitochondrial protein that may have important functions in regulating mitochondrial physiology.

TL;DR: Data suggest that Müller cells play a prominent role in the water handling in the retina and that they direct osmotically driven water flux to the vitreous body and vessels rather than to the subretinal space.

TL;DR: While the intensity of the labelling for GLAST and GLT1 varied among different regions, their cellular distributions appeared to coincide inasmuch as both mRNAs were mainly expressed by glial cells.