R
Renate Artmann
Researcher at Ludwig Maximilian University of Munich
Publications - 9
Citations - 251
Renate Artmann is an academic researcher from Ludwig Maximilian University of Munich. The author has contributed to research in topics: Hepatic stellate cell & Fibrosis. The author has an hindex of 7, co-authored 8 publications receiving 189 citations.
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Journal ArticleDOI
Progressive stages of mitochondrial destruction caused by cell toxic bile salts.
Sabine Schulz,Sabine Schmitt,Ralf Wimmer,Michaela Aichler,Sabine Eisenhofer,Josef Lichtmannegger,Carola Eberhagen,Renate Artmann,Ferenc Tookos,Axel Walch,Daniel Krappmann,Catherine Brenner,Christian Rust,Hans Zischka +13 more
TL;DR: It is demonstrated that GCDCA and TCDCA, but not TUDCA, preferentially permeabilize liposomes containing the mitochondrial membrane protein ANT, a process resembling the MPT induction in whole mitochondria, which suggests that ANT is one decisive target for toxic bile salts.
Journal ArticleDOI
Mitochondrial adaptation in steatotic mice.
Claudia Einer,Simon Hohenester,Ralf Wimmer,Lena Wottke,Renate Artmann,Sabine Schulz,Christian Gosmann,Alisha Simmons,Christin Leitzinger,Carola Eberhagen,Sabine Borchard,Sabine Schmitt,Stefanie M. Hauck,Christine von Toerne,Martin Jastroch,Ellen Walheim,Christian Rust,Alexander L. Gerbes,Bastian Popper,Doris Mayr,Max Schnurr,Angelika M. Vollmar,Gerald Denk,Hans Zischka +23 more
TL;DR: WD-mitochondria do not promote steatotic wild type and immune-compromised mice fed a Western diet, but demonstrate bioenergetic deficits and increased sensitivity to stress signals.
Journal ArticleDOI
1,25-(OH)₂-vitamin D₃ prevents activation of hepatic stellate cells in vitro and ameliorates inflammatory liver damage but not fibrosis in the Abcb4(-/-) model.
Florian P. Reiter,Simon Hohenester,Jutta M. Nagel,Ralf Wimmer,Renate Artmann,Lena Wottke,Marie-Christine Makeschin,Doris Mayr,Christian Rust,Michael Trauner,Gerald Denk +10 more
TL;DR: Test the hypothesis that active 1,25-(OH)2-vitamin D3 inhibits activation of hepatic stellate cells (HSC) in vitro and modulates liver-injury in vivo and calcitriol ameliorates inflammatory liver-damage but has no effect on biliary fibrosis.
Journal ArticleDOI
Role of interleukin-1 and its antagonism of hepatic stellate cell proliferation and liver fibrosis in the Abcb4(-/-) mouse model.
Florian P. Reiter,Ralf Wimmer,Lena Wottke,Renate Artmann,Jutta M. Nagel,Manuel O Carranza,Doris Mayr,Christian Rust,Peter Fickert,Michael Trauner,Alexander L. Gerbes,Simon Hohenester,Gerald Denk +12 more
TL;DR: Liver fibrosis was less pronounced in males than in female Abcb4(-/-) animals as defined by a lower hydroxyproline content and Sirius red staining, and the administration of IL-1β resulted in a significant increase in HSC proliferation, in vitro and in vivo.
Journal ArticleDOI
Lifestyle intervention for morbid obesity: effects on liver steatosis, inflammation, and fibrosis
Simon Hohenester,Simon Christiansen,Jutta M. Nagel,Ralf Wimmer,Renate Artmann,Gerald Denk,Monika Bischoff,Gert Bischoff,Christian Rust +8 more
TL;DR: New evidence is demonstrated that lifestyle intervention is effective in treating NAFLD in the important group of patients with (morbid) obesity, and patients with weight loss of >10% seemed to benefit most.