Thierry Galli

TL;DR: This work used a high-throughput yeast two-hybrid (Y2H)-based technology to screen 102 bait proteins from Drosophila melanogaster, most of them orthologous to human cancer-related and/or signaling proteins, against high-complexity fly cDNA libraries.

TL;DR: This study shows that membrane exchange between the early endocytic and the biosynthetic/secretory pathways involves specific components of the Rab and SNARE machinery, and suggests that retrograde transport between early/recycling endosomes and the endoplasmic reticulum is critically dependent on the sequential action of two members of therab6 subfamily.

TL;DR: The results suggest that Rab11 influences endosome to TGN trafficking primarily by regulating membrane distribution inside the early endosomal pathway.

TL;DR: The pathway of Tfn receptor recycling consists of at least two biochemically and functionally distinct populations of endosomes, a Rab4-positive population of early endosome to which incoming Tfn is initially delivered and a Rab 4-negative population of recycling vesicles that transiently accumulates Tfn on its route back to the plasma membrane.

TL;DR: This study found that syntaxin 3, SNAP23, and a newly identified VAMP/brevin, tetanus neurotoxin (TeNT)-insensitive VAMP (TI-VAMP), are insensitive to clostridial NTs and are suggested to participate in exocytotic processes at the apical plasma membrane of epithelial cells and, more generally, domain-specificExocytosis in clostidial NT-resistant pathways.