H
Hélène Botella
Researcher at Centre national de la recherche scientifique
Publications - 5
Citations - 516
Hélène Botella is an academic researcher from Centre national de la recherche scientifique. The author has contributed to research in topics: Immune system & Innate immune system. The author has an hindex of 3, co-authored 4 publications receiving 459 citations. Previous affiliations of Hélène Botella include Paul Sabatier University.
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Journal ArticleDOI
Mycobacterial P1-Type ATPases Mediate Resistance to Zinc Poisoning in Human Macrophages
Hélène Botella,Hélène Botella,Pascale Peyron,Pascale Peyron,Florence Levillain,Florence Levillain,Renaud Poincloux,Renaud Poincloux,Yannick Poquet,Yannick Poquet,Irène Brandli,Irène Brandli,Irène Brandli,Chuan Wang,Chuan Wang,Chuan Wang,Ludovic Tailleux,Sylvain Tilleul,Guillaume M. Charrière,Guillaume M. Charrière,Simon J. Waddell,Maria Foti,Geanncarlo Lugo-Villarino,Geanncarlo Lugo-Villarino,Qian Gao,Isabelle Maridonneau-Parini,Isabelle Maridonneau-Parini,Philip D. Butcher,Paola Ricciardi Castagnoli,Brigitte Gicquel,Chantal de Chastellier,Chantal de Chastellier,Chantal de Chastellier,Olivier Neyrolles,Olivier Neyrolles +34 more
TL;DR: The use of P1-type ATPases represents a M. tuberculosis strategy to neutralize the toxic effects of zinc in macrophages, suggesting that heavy metal toxicity and its counteraction might represent yet another chapter in the host-microbe arms race.
Journal ArticleDOI
A murine DC-SIGN homologue contributes to early host defense against Mycobacterium tuberculosis
Antoine Tanne,Bo Ma,Frédéric Boudou,Ludovic Tailleux,Hélène Botella,Edgar Badell,Florence Levillain,Maureen E. Taylor,Kurt Drickamer,Jérôme Nigou,Karen M. Dobos,Germain Puzo,Dietmar Vestweber,Martin K. Wild,Marie Marcinko,Peter Sobieszczuk,Lauren Stewart,Daniel Lebus,Brigitte Gicquel,Olivier Neyrolles,Olivier Neyrolles +20 more
TL;DR: The mouse DC-SIGN homologue SIGNR3 makes a unique contribution to protection of the host against a pulmonary bacterial pathogen.
Journal ArticleDOI
Metallobiology of host-pathogen interactions: an intoxicating new insight.
Hélène Botella,Gustavo Stadthagen,Gustavo Stadthagen,Geanncarlo Lugo-Villarino,Geanncarlo Lugo-Villarino,Chantal de Chastellier,Chantal de Chastellier,Chantal de Chastellier,Olivier Neyrolles,Olivier Neyrolles +9 more
TL;DR: These exciting advancements implicating copper- and zinc-mediated microbial poisoning as a novel innate immune mechanism against microbial pathogens are focused on, shedding light on an emerging field in the metallobiology of host-pathogen interactions.
Journal ArticleDOI
Reframing antimicrobial resistance as a continuous spectrum of manifestations.
TL;DR: In this paper , the authors present an integrated view of AMR by reframing it as a spectrum of phenotypes within a continuous three-dimensional space defined by the growth rate, prevalence, and kill rate of cells displaying AMR.
Journal ArticleDOI
Un rôle nouveau des métaux de transition dans l’immunité antimicrobienne
Hélène Botella,Hélène Botella,Gustavo Stadthagen,Gustavo Stadthagen,Chantal de Chastellier,Chantal de Chastellier,Chantal de Chastellier,Olivier Neyrolles,Olivier Neyrolles +8 more
TL;DR: Dendritic cellspecific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN)-mediated enhancement of dengue virus infection is independent of DC-SIGN internalization signals.