Rene Hoet

TL;DR: The construction of human Fab libraries having a unique combination of immunoglobulin sequences captured from human donors and synthetic diversity in key antigen contact sites in heavy-chain complementarity-determining regions 1 and 2 are reported.

TL;DR: In this paper, the authors used a highly selective fully human MMP-14 inhibitory antibody discovered using phage display technology, which blocked proMMP-2 processing on tumor and endothelial cells, inhibited angiogenesis, and slowed tumor progression and formation of metastatic lesions.

TL;DR: The design of an Ab repertoire enriched in Abs binding to small charged carbohydrates and the construction of a human Fab phagemid library, “FAB-CCHO,” are reported.

TL;DR: In this paper, the authors present methods useful in constructing libraries that collectively display and/or express members of diverse families of peptides, polypeptides or proteins and the libraries produced using those methods.

TL;DR: In this paper, a flow chamber is configured such that a first magnetic field can be selectively applied in the flow chamber, and a flow of fluid can also be applied to the chamber in coordination with the selective application of the magnetic field.