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Richard A. Kroczek
Researcher at Robert Koch Institute
Publications - 85
Citations - 12417
Richard A. Kroczek is an academic researcher from Robert Koch Institute. The author has contributed to research in topics: T cell & Cytotoxic T cell. The author has an hindex of 48, co-authored 85 publications receiving 11788 citations.
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Journal ArticleDOI
CD40 ligand on activated platelets triggers an inflammatory reaction of endothelial cells
Volker Henn,Joseph R. Slupsky,Michael Gräfe,Ioannis Anagnostopoulos,Reinhold Förster,Gert Müller-Berghaus,Richard A. Kroczek +6 more
TL;DR: In this paper, platelets express CD40L within seconds of activation in vitro and in the process of thrombus formation in vivo, indicating that platelets are not only involved in haemostasis but that they also directly initiate an inflammatory response of the vessel wall.
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ICOS is an inducible T-cell co-stimulator structurally and functionally related to CD28
Andreas Hutloff,Anna M. Dittrich,Katja C. Beier,Barbara Eljaschewitsch,Regine Kraft,Ionnis Anagnostopoulos,Richard A. Kroczek +6 more
TL;DR: The identification of a third member of this family of molecules, inducible co-stimulator (ICOS), which is a homodimeric protein of relative molecular mass 55,000–60,000 (Mr 55K–60K) indicates that ICOS is another major regulator of the adaptive immune system.
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Defective expression of T-cell CD40 ligand causes X-linked immunodeficiency with hyper-IgM
Ulf Korthäuer,Daniel Graf,Hans W. Mages,Francine Brière,M Padayachee,Sue Malcolm,Alberto G. Ugazio,Luigi D. Notarangelo,Roland J. Levinsky,Richard A. Kroczek +9 more
TL;DR: Evidence is presented that point mutations in the TRAP gene give rise to nonfunctional or defective expression of TRAP on the surface of T cells in patients with HIGM1, which is responsible for the observed immunoglobulin isotype defect in HIGm1.
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Homozygous loss of ICOS is associated with adult-onset common variable immunodeficiency
Bodo Grimbacher,Andreas Hutloff,Michael Schlesier,Erik Glocker,Klaus Warnatz,Ruth Dräger,Hermann Eibel,Beate Fischer,Alejandro A. Schäffer,Hans W. Mages,Richard A. Kroczek,Hans H. Peter +11 more
TL;DR: The phenotype of human ICOS deficiency, which differs in key aspects from that of the ICOS−/− mouse, suggests a critical involvement of ICOS in T cell help for late B cell differentiation, class-switching and memory B cell generation.
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The inflammatory action of CD40 ligand (CD154) expressed on activated human platelets is temporally limited by coexpressed CD40
TL;DR: The findings indicate that the interaction of platelet CD154 with CD40 on neighboring cells is temporally limited to prevent an uncontrolled inflammation at the site of thrombus formation.