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Richard B. Lanman
Researcher at Nuclear Regulatory Commission
Publications - 217
Citations - 11412
Richard B. Lanman is an academic researcher from Nuclear Regulatory Commission. The author has contributed to research in topics: Cancer & Lung cancer. The author has an hindex of 47, co-authored 210 publications receiving 8078 citations. Previous affiliations of Richard B. Lanman include Northwestern University.
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Journal ArticleDOI
Preoperative Diagnosis of Benign Thyroid Nodules with Indeterminate Cytology
Erik K. Alexander,Giulia C. Kennedy,Zubair W. Baloch,Edmund S. Cibas,Darya Chudova,James C. Diggans,Lyssa Friedman,Richard T. Kloos,Virginia A. LiVolsi,Susan J. Mandel,Stephen S. Raab,Juan Rosai,David L. Steward,P. Sean Walsh,Jonathan I. Wilde,Martha A. Zeiger,Richard B. Lanman,Bryan R. Haugen +17 more
TL;DR: Consideration of a more conservative approach for most patients with thyroid nodules that are cytologically indeterminate on fine-needle aspiration and benign according to gene-expression classifier results are suggested.
Journal ArticleDOI
Analytical and clinical validation of a digital sequencing panel for quantitative, highly accurate evaluation of cell-free circulating tumor DNA
Richard B. Lanman,Stefanie Mortimer,Oliver A. Zill,Dragan Sebisanovic,Rene Lopez,Sibel Blau,Eric A. Collisson,Stephen G. Divers,Dave S.B. Hoon,E. Scott Kopetz,Jeeyun Lee,Petros Nikolinakos,Arthur Baca,Bahram G. Kermani,Helmy Eltoukhy,Amir Ali Talasaz +15 more
TL;DR: The analytic and clinical validation of the gene panel are reported and near-perfect analytic specificity enables complete coverage of many genes without the false positives typically seen with traditional sequencing assays at mutant allele frequencies or fractions below 5%.
Journal ArticleDOI
Evolution and clinical impact of co-occurring genetic alterations in advanced-stage EGFR-mutant lung cancers
Collin M. Blakely,Thomas B.K. Watkins,Wei Wu,Beatrice Gini,Jacob J. Chabon,Caroline E. McCoach,Nicholas McGranahan,Gareth A. Wilson,Nicolai Juul Birkbak,Victor Olivas,Julia K Rotow,Ashley Maynard,Victoria E. Wang,Matthew A. Gubens,Kimberly C. Banks,Richard B. Lanman,Aleah F. Caulin,John St. John,Anibal Cordero,Petros Giannikopoulos,Andrew Simmons,Philip C. Mack,David R. Gandara,Hatim Husain,Robert C. Doebele,Jonathan W. Riess,Maximilian Diehn,Charles Swanton,Trever G. Bivona +28 more
TL;DR: This study calls for revisiting the prevailing single-gene driver-oncogene view and links clinical outcomes to co-occurring genetic alterations in patients with advanced-stage EGFR-mutant lung cancer.
Journal ArticleDOI
Clinical Utility of Comprehensive Cell-free DNA Analysis to Identify Genomic Biomarkers in Patients with Newly Diagnosed Metastatic Non-small Cell Lung Cancer.
Natasha B. Leighl,Ray D. Page,Victoria M. Raymond,Davey B. Daniel,Stephen G. Divers,Karen L. Reckamp,Miguel A. Villalona-Calero,Daniel Dix,Justin I. Odegaard,Richard B. Lanman,Vassiliki A. Papadimitrakopoulou +10 more
TL;DR: In the largest cfDNA study in previously untreated mNSCLC, a validated comprehensive cfDNA test identifies guideline-recommended biomarkers at a rate at least as high as SOC tissue genotyping, with high tissue concordance, more rapidly and completely than tissue-based genotypesing.
Journal ArticleDOI
A Large Multicenter Correlation Study of Thyroid Nodule Cytopathology and Histopathology
Chung Che Charles Wang,Lyssa Friedman,Giulia C. Kennedy,Hui Wang,Electron Kebebew,David L. Steward,Martha A. Zeiger,William H. Westra,Yongchun Wang,Elham Khanafshar,Giovanni Fellegara,Juan Rosai,Virginia A. LiVolsi,Richard B. Lanman +13 more
TL;DR: High disagreement rates between local and expert panel histopathology diagnosis suggests that central review for surgical diagnoses should be used when developing diagnostic tests based on resected thyroid specimens.