O
Oliver A. Zill
Researcher at Genentech
Publications - 30
Citations - 2264
Oliver A. Zill is an academic researcher from Genentech. The author has contributed to research in topics: Cancer & KRAS. The author has an hindex of 13, co-authored 27 publications receiving 1750 citations. Previous affiliations of Oliver A. Zill include California Institute for Quantitative Biosciences & University of California, San Francisco.
Papers
More filters
Journal ArticleDOI
Analytical and clinical validation of a digital sequencing panel for quantitative, highly accurate evaluation of cell-free circulating tumor DNA
Richard B. Lanman,Stefanie Mortimer,Oliver A. Zill,Dragan Sebisanovic,Rene Lopez,Sibel Blau,Eric A. Collisson,Stephen G. Divers,Dave S.B. Hoon,E. Scott Kopetz,Jeeyun Lee,Petros Nikolinakos,Arthur Baca,Bahram G. Kermani,Helmy Eltoukhy,Amir Ali Talasaz +15 more
TL;DR: The analytic and clinical validation of the gene panel are reported and near-perfect analytic specificity enables complete coverage of many genes without the false positives typically seen with traditional sequencing assays at mutant allele frequencies or fractions below 5%.
Journal ArticleDOI
The Awesome Power of Yeast Evolutionary Genetics: New Genome Sequences and Strain Resources for the Saccharomyces sensu stricto Genus
Devin R. Scannell,Oliver A. Zill,Antonis Rokas,Celia Payen,Maitreya J. Dunham,Michael B. Eisen,Michael B. Eisen,Jasper Rine,Mark Johnston,Mark Johnston,Chris Todd Hittinger,Chris Todd Hittinger +11 more
TL;DR: Improved genome sequences of three species of Saccharomyces sensu stricto yeasts are presented, enabling a re-examination of the tempo and mode of yeast gene evolution and improved inferences of species-specific gains and losses, and genetically marked, stable haploid strains are generated for all three species.
Journal ArticleDOI
Validation of a Plasma-Based Comprehensive Cancer Genotyping Assay Utilizing Orthogonal Tissue- And Plasma-Based Methodologies
Justin I. Odegaard,John J. Vincent,Stefanie Mortimer,James V. Vowles,Bryan C. Ulrich,Kimberly C. Banks,Stephen R. Fairclough,Oliver A. Zill,Marcin Sikora,Reza Bayat Mokhtari,Diana Abdueva,Rebecca J. Nagy,Christine E. Lee,Lesli A. Kiedrowski,Cloud P. Paweletz,Helmy Eltoukhy,Richard B. Lanman,Darya Chudova,AmirAli Talasaz +18 more
TL;DR: High concordance with orthogonal clinical plasma- and tissue-based genotyping methods supports the clinical accuracy of digital sequencing across all four types of targetable genomic alterations.
Journal ArticleDOI
The landscape of actionable genomic alterations in cell-free circulating tumor DNA from 21,807 advanced cancer patients
Oliver A. Zill,Kimberly C. Banks,Stephen R. Fairclough,Stefanie Mortimer,James V. Vowles,Reza Mokhtari,David R. Gandara,Philip C. Mack,Justin I. Odegaard,Rebecca J. Nagy,Arthur Baca,Helmy Eltoukhy,Darya Chudova,Richard B. Lanman,AmirAli Talasaz +14 more
TL;DR: Together, these retrospective analyses of a large cfDNA sequencing data set reveal subclonal structures and emerging resistance in advanced solid tumors.
Journal ArticleDOI
Cell-Free DNA Next-Generation Sequencing in Pancreatobiliary Carcinomas
Oliver A. Zill,Claire Greene,Dragan Sebisanovic,Lai Mun Siew,Jim Leng,Mary Vu,Andrew Eugene Hendifar,Zhen Wang,Chloe E. Atreya,Robin Kate Kelley,Katherine Van Loon,Andrew H. Ko,Margaret A. Tempero,Trever G. Bivona,Pamela N. Munster,AmirAli Talasaz,Eric A. Collisson +16 more
TL;DR: It is demonstrated that cfDNA sequencing reliably and accurately detects tumor-derived mutations, paving the way for precision oncology approaches in these deadly diseases.