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Richard B. Miles

Researcher at Texas A&M University

Publications -  790
Citations -  27199

Richard B. Miles is an academic researcher from Texas A&M University. The author has contributed to research in topics: Laser & Rayleigh scattering. The author has an hindex of 78, co-authored 759 publications receiving 25239 citations. Previous affiliations of Richard B. Miles include Pierre-and-Marie-Curie University & Langley Research Center.

Papers
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Differences between somatic and dendritic inhibition in the hippocampus

TL;DR: Hippocampal synaptic inhibition is mediated by distinct groups of inhibitory cells that may differentially control dendritic electrogenesis and axonal output of hippocampal pyramidal cells.
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On the origin of interictal activity in human temporal lobe epilepsy in vitro.

TL;DR: A spontaneous, rhythmic activity initiated in the subiculum of slices from patients with temporal lobe epilepsy was described, similar to interictal discharges of patient electroencephalograms.
Book

Neuronal Networks of the Hippocampus

TL;DR: Using a combined experimental-theoretical approach unique in neuroscience, the authors present important new techniques for the physiological reconstruction of a large biological neuronal network in the CA3 hippocampal region in vitro.
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A model of a CA3 hippocampal pyramidal neuron incorporating voltage-clamp data on intrinsic conductances.

TL;DR: After these alterations, tonic depolarization of the soma leads to adapting repetitive firing, whereas stimulation of the distal dendrites leads to bursting, and a critical set of parameters concerns the regulation of the pool of intracellular [Ca2+] that interacts with membrane channels (gK(C) and gK(AHP)), particularly in the dendrite.
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Perturbed Chloride Homeostasis and GABAergic Signaling in Human Temporal Lobe Epilepsy

TL;DR: It is observed that all cells that were hyperpolarized during interictal events were immunopositive for KCC2, whereas the majority of depolarized cells were immunonegative.