R
Richard Cadagan
Researcher at Icahn School of Medicine at Mount Sinai
Publications - 6
Citations - 340
Richard Cadagan is an academic researcher from Icahn School of Medicine at Mount Sinai. The author has contributed to research in topics: Virus & Epitope. The author has an hindex of 5, co-authored 6 publications receiving 290 citations.
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Journal ArticleDOI
Maternal Influenza Viral Infection Causes Schizophrenia-Like Alterations of 5-HT2A and mGlu2 Receptors in the Adult Offspring
José L. Moreno,Mitsumasa Kurita,Terrell Holloway,Javier López,Richard Cadagan,Luis Martinez-Sobrido,Adolfo García-Sastre,Javier González-Maeso +7 more
TL;DR: It is shown that spontaneous locomotor activity is diminished by maternal infection with the mouse-adapted influenza A/WSN/33 (H1N1) virus, and it is found that the cortical 5-HT2A receptor-dependent signaling pathways are significantly altered in the offspring of infected mothers, showing higher c-fos, egr-1, and eGr-2 expression in response to the hallucinogenic drug DOI.
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Hemagglutinin-Pseudotyped Green Fluorescent Protein-Expressing Influenza Viruses for the Detection of Influenza Virus Neutralizing Antibodies
Luis Martinez-Sobrido,Richard Cadagan,John Steel,Christopher F. Basler,Peter Palese,Thomas M. Moran,Adolfo García-Sastre +6 more
TL;DR: The development of a simple, sensitive, specific, and safe screening assay for the rapid detection of NAbs against highly pathogenic influenza viruses under biosafety level 2 (BSL-2) conditions is described.
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Dengue Virus Immunity Increases Zika Virus-Induced Damage during Pregnancy
Julia A. Brown,Gursewak Singh,Joshua A. Acklin,Silviana Lee,James Duehr,Anupa Chokola,Justin J. Frere,Kevin W. Hoffman,Gregory A. Foster,David E. Krysztof,Richard Cadagan,Adam Jacobs,Susan L. Stramer,Florian Krammer,Adolfo García-Sastre,Jean K. Lim +15 more
TL;DR: The presence of DENV‐specific antibodies in ZIKV‐infected pregnant mice significantly increased placental damage, fetal growth restriction, and fetal resorption and was associated with enhanced viral replication in the placenta that coincided with an increased frequency of infected trophoblasts.
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Functional Characterization and Direct Comparison of Influenza A, B, C, and D NS1 Proteins in vitro and in vivo
Aitor Nogales,Teresa Aydillo,Ginés Ávila-Pérez,Alba Escalera,Kevin Chiem,Richard Cadagan,Marta L. DeDiego,Feng Li,Adolfo García-Sastre,Luis Martinez-Sobrido +9 more
TL;DR: It is suggested that despite the similarities to effectively counteract innate immune responses in vitro, the NS1 proteins of IBV, ICV, or IDV do not fully complement the functions of IAV NS1, resulting in deficient viral replication and pathogenesis in vivo.
Journal ArticleDOI
The immunological potency and therapeutic potential of a prototype dual vaccine against influenza and Alzheimer's disease
Hayk Davtyan,Anahit Ghochikyan,Richard Cadagan,Dmitriy Zamarin,Irina Petrushina,Nina Movsesyan,Luis Martinez-Sobrido,Randy A. Albrecht,Adolfo García-Sastre,Michael G. Agadjanyan +9 more
TL;DR: A novel chimeric flu vaccine expressing the small immunodominant B cell epitope of Aβ42 is created that might be beneficial for treatment of AD patients as well as for prevention of development of AD pathology in pre-symptomatic individuals while concurrently boosting immunity against influenza.