Dengue Virus Immunity Increases Zika Virus-Induced Damage during Pregnancy
Julia A. Brown,Gursewak Singh,Joshua A. Acklin,Silviana Lee,James Duehr,Anupa Chokola,Justin J. Frere,Kevin W. Hoffman,Gregory A. Foster,David E. Krysztof,Richard Cadagan,Adam Jacobs,Susan L. Stramer,Florian Krammer,Adolfo García-Sastre,Jean K. Lim +15 more
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TLDR
The presence of DENV‐specific antibodies in ZIKV‐infected pregnant mice significantly increased placental damage, fetal growth restriction, and fetal resorption and was associated with enhanced viral replication in the placenta that coincided with an increased frequency of infected trophoblasts.About:
This article is published in Immunity.The article was published on 2019-03-19 and is currently open access. It has received 83 citations till now. The article focuses on the topics: Dengue virus & Antibody-dependent enhancement.read more
Citations
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Journal ArticleDOI
Antibody-Dependent Enhancement: A Challenge for Developing a Safe Dengue Vaccine.
TL;DR: The generation of type-specific antibodies to each of the four DENV serotypes by the designed vaccines could avoid the immune evasion mechanisms of DENVs and thus avoid the ADE phenomenon largely associated with the prM and FLE antibodies.
Journal ArticleDOI
Cross-Reactive Immunity Among Flaviviruses.
TL;DR: The knowledge of the functional immune outcomes that arise from varied flaviviral immune statuses are described and the cross-reactive antibody and T cell immune responses that are protective versus pathological are addressed.
Journal ArticleDOI
A protective Zika virus E-dimer-based subunit vaccine engineered to abrogate antibody-dependent enhancement of dengue infection.
J Slon-Campos,Wanwisa Dejnirattisai,Brett W. Jagger,Brett W. Jagger,Cesar Lopez-Camacho,Wiyada Wongwiwat,Lorellin A. Durnell,Emma S. Winkler,Rita E. Chen,Arturo Reyes-Sandoval,Félix A. Rey,Félix A. Rey,Michael S. Diamond,Juthathip Mongkolsapaya,Juthathip Mongkolsapaya,Gavin R. Screaton +15 more
TL;DR: A protective Zika virus E-dimer-based subunit vaccine engineered to abrogate antibody-dependent enhancement of dengue infection is described, which protects against ZIKV challenge during pregnancy and does not cross-react with DENV or induce ADE of DENV infection.
Journal ArticleDOI
Comprehensive analysis of COVID-19 during pregnancy.
TL;DR: In this article, the authors examined key aspects of pregnancy that may be impacted by COVID-19 and summarized the current literature on SARS-CoV-2 infection of the placenta and in utero vertical transmission.
Journal ArticleDOI
A Zika virus envelope mutation preceding the 2015 epidemic enhances virulence and fitness for transmission.
Chao Shan,Hongjie Xia,Sherry L. Haller,Sasha R. Azar,Yang Liu,Jianying Liu,Antonio E. Muruato,Rubing Chen,Shannan L. Rossi,Maki Wakamiya,Nikos Vasilakis,Rongjuan Pei,Camila R. Fontes-Garfias,Sanjay K. Singh,Xuping Xie,Scott C. Weaver,Pei Yong Shi +16 more
TL;DR: Overall, this study revealed E-V473M as a critical determinant for enhanced ZIKV virulence, intrauterine transmission during pregnancy, and viremia to facilitate urban transmission.
References
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Journal ArticleDOI
Zika Virus Associated with Microcephaly
Jernej Mlakar,Miša Korva,Mateja Poljšak-Prijatelj,Jerica Mraz,Marko Kolenc,Katarina Resman Rus,Tina Vesnaver Vipotnik,Vesna Fabjan,Alenka Vizjak,Miroslav Petrovec +9 more
TL;DR: The case of an expectant mother who had a febrile illness with rash at the end of the first trimester of pregnancy while she was living in Brazil and revealed microcephaly with calcifications in the fetal brain and placenta is described.
Journal ArticleDOI
Zika Virus Infection in Pregnant Women in Rio de Janeiro - Preliminary Report.
Abstr Act,Patrícia Brasil,Jose Paulo Pereira,Claudia Raja Gabaglia,Luana Damasceno,Mayumi Duarte Wakimoto,Rita Maria Ribeiro Nogueira,Patricia Carvalho de Sequeira,André M. Siqueira,Liege Maria Abreu de Carvalho,Denise Cotrim da Cunha,Guilherme Amaral Calvet,Elizabeth de Souza Neves,Maria Elisabeth Lopes Moreira,Ana Elisa Rodrigues Baião,Paulo Roberto Nassar de Carvalho,Carla Janzen,Stephanie G. Valderramos,James D. Cherry,Ana Maria Bispo de Filippis,Karin Nielsen-Saines +20 more
TL;DR: Despite mild clinical symptoms in the mother, ZIKV infection during pregnancy is deleterious to the fetus and is associated with fetal death, fetal growth restriction, and a spectrum of central nervous system abnormalities.
Journal ArticleDOI
Pathogenesis of dengue: challenges to molecular biology
TL;DR: This work has identified a severe syndrome, dengue hemorrhagic fever/dengue shock syndrome, in Southeast Asian children, which recently has also been identified in children infected with the virus in Puerto Rico.
Journal ArticleDOI
Dengue Viremia Titer, Antibody Response Pattern, and Virus Serotype Correlate with Disease Severity
David W. Vaughn,Sharone Green,Siripen Kalayanarooj,Bruce L. Innis,Suchitra Nimmannitya,Saroj Suntayakorn,Timothy P. Endy,Boonyos Raengsakulrach,Alan L. Rothman,Francis A. Ennis,Ananda Nisalak +10 more
TL;DR: Higher peak titers were associated with increased disease severity for the 31 patients with a peak titer identified, and increased dengue disease severity correlated with high viremia titer, secondary d Dengue virus infection, and DEN-2 virus type.
Journal ArticleDOI
Dengue virus sero-cross-reactivity drives antibody-dependent enhancement of infection with zika virus
Wanwisa Dejnirattisai,Piyada Supasa,Piyada Supasa,Wiyada Wongwiwat,Alexander Rouvinski,Giovanna Barba-Spaeth,Giovanna Barba-Spaeth,Thaneeya Duangchinda,Anavaj Sakuntabhai,Anavaj Sakuntabhai,Van-Mai Cao-Lormeau,Prida Malasit,Prida Malasit,Félix A. Rey,Félix A. Rey,Juthathip Mongkolsapaya,Juthathip Mongkolsapaya,Gavin R. Screaton +17 more
TL;DR: Plasma immune to DENV showed substantial cross-reaction to ZIKV and was able to drive antibody-dependent enhancement (ADE) of ZikaV infection, indicating that immunity toDENV might drive greater ZikV replication and have clear implications for disease pathogenesis and future vaccine programs.
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Dengue virus sero-cross-reactivity drives antibody-dependent enhancement of infection with zika virus
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Zika Virus Infection in Pregnant Women in Rio de Janeiro - Preliminary Report.
Abstr Act,Patrícia Brasil,Jose Paulo Pereira,Claudia Raja Gabaglia,Luana Damasceno,Mayumi Duarte Wakimoto,Rita Maria Ribeiro Nogueira,Patricia Carvalho de Sequeira,André M. Siqueira,Liege Maria Abreu de Carvalho,Denise Cotrim da Cunha,Guilherme Amaral Calvet,Elizabeth de Souza Neves,Maria Elisabeth Lopes Moreira,Ana Elisa Rodrigues Baião,Paulo Roberto Nassar de Carvalho,Carla Janzen,Stephanie G. Valderramos,James D. Cherry,Ana Maria Bispo de Filippis,Karin Nielsen-Saines +20 more