R
Robin B. Lee
Researcher at St. Jude Children's Research Hospital
Publications - 18
Citations - 990
Robin B. Lee is an academic researcher from St. Jude Children's Research Hospital. The author has contributed to research in topics: Mycobacterium tuberculosis & Tuberculosis. The author has an hindex of 13, co-authored 18 publications receiving 839 citations. Previous affiliations of Robin B. Lee include University of Tennessee Health Science Center.
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Journal ArticleDOI
New agents for the treatment of drug-resistant Mycobacterium tuberculosis
TL;DR: The challenges to developing drugs to treat tuberculosis are discussed and how the field has adapted to these difficulties, with an emphasis on drug discovery approaches that might produce more effective agents and treatment regimens.
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Spectinamides: a new class of semisynthetic antituberculosis agents that overcome native drug efflux
Richard E. Lee,Julian G. Hurdle,Jiuyu Liu,David F. Bruhn,Tanja Matt,Michael S. Scherman,Pavan K. Vaddady,Zhong Zheng,Jianjun Qi,Rashid Akbergenov,Sourav Das,Dora B. Madhura,Chetan Rathi,Ashit Trivedi,Cristina Villellas,Robin B. Lee,Rakesh,Samanthi L. Waidyarachchi,Dianqing Sun,Michael R. McNeil,José A. Aínsa,Helena I. Boshoff,Mercedes Gonzalez-Juarrero,Bernd Meibohm,Erik C. Böttger,Anne J. Lenaerts +25 more
TL;DR: The antitubercular efficacy of spectinamides demonstrates that synthetic modifications to classical antibiotics can overcome the challenge of intrinsic efflux pump-mediated resistance and expands opportunities for target-based tuberculosis drug discovery.
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A microbiological assessment of novel nitrofuranylamides as anti-tuberculosis agents
Julian G. Hurdle,Robin B. Lee,Nageshwar R. Budha,Elizabeth I. Carson,Jianjun Qi,Michael S. Scherman,Sang-Hyun Cho,Michael R. McNeil,Anne J. Lenaerts,Scott G. Franzblau,Bernd Meibohm,Richard E. Lee +11 more
TL;DR: NFAs have many useful antimycobacterial properties applicable to TB chemotherapy and probably possess a unique mode of action that results in good activity against active and dormant M. tuberculosis.
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Synthesis, structure-activity relationship studies, and antibacterial evaluation of 4-chromanones and chalcones, as well as olympicin A and derivatives
Li Feng,Marcus M. Maddox,Zahidul Alam,Lissa S. Tsutsumi,Gagandeep Narula,David F. Bruhn,Xiaoqian Wu,Shayna Sandhaus,Robin B. Lee,Charles J. Simmons,Yuk-Ching Tse-Dinh,Julian G. Hurdle,Richard E. Lee,Dianqing Sun +13 more
TL;DR: Mode of action studies performed on selected compounds revealed that they dissipated the bacterial membrane potential, resulting in the inhibition of macromolecular biosynthesis; further studies showed that selected compounds inhibited DNA topoisomerase IV, suggesting complex mechanisms of actions for compounds in this series.
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Synthesis, Optimization and Structure-Activity Relationships of 3,5-Disubstituted Isoxazolines as New Anti-tuberculosis Agents
TL;DR: Attempts to replace the ester group at C-3 position of isoxazoline with a variety of bioisosteric head groups led to significant loss of the tuberculosis inhibition indicating that an ester is required for anti-tuberculosis activity.