J
Jianjun Qi
Researcher at University of Tennessee Health Science Center
Publications - 16
Citations - 1085
Jianjun Qi is an academic researcher from University of Tennessee Health Science Center. The author has contributed to research in topics: Dihydropteroate synthase & Pterin. The author has an hindex of 11, co-authored 12 publications receiving 878 citations. Previous affiliations of Jianjun Qi include St. Jude Children's Research Hospital.
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Journal ArticleDOI
Validation of molecular docking programs for virtual screening against dihydropteroate synthase.
Kirk E. Hevener,Wei Zhao,Wei Zhao,David M. Ball,David M. Ball,Kerim Babaoglu,Kerim Babaoglu,Jianjun Qi,Jianjun Qi,Stephen W. White,Stephen W. White,Richard E. Lee,Richard E. Lee +12 more
TL;DR: Of the docking and scoring functions evaluated, Surflex with Surflex-Score and Glide with GlideScore were the best overall performers for use in virtual screening against the DHPS target, with neither combination showing statistically significant superiority over the other in enrichment studies or pose selection.
Journal ArticleDOI
Acyl-Phosphates Initiate Membrane Phospholipid Synthesis in Gram-Positive Pathogens
TL;DR: The PlsX/Y pathway defines the most widely distributed pathway for the initiation of phospholipid formation in bacteria and represents a new target for the development of antibacterial therapeutics.
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Spectinamides: a new class of semisynthetic antituberculosis agents that overcome native drug efflux
Richard E. Lee,Julian G. Hurdle,Jiuyu Liu,David F. Bruhn,Tanja Matt,Michael S. Scherman,Pavan K. Vaddady,Zhong Zheng,Jianjun Qi,Rashid Akbergenov,Sourav Das,Dora B. Madhura,Chetan Rathi,Ashit Trivedi,Cristina Villellas,Robin B. Lee,Rakesh,Samanthi L. Waidyarachchi,Dianqing Sun,Michael R. McNeil,José A. Aínsa,Helena I. Boshoff,Mercedes Gonzalez-Juarrero,Bernd Meibohm,Erik C. Böttger,Anne J. Lenaerts +25 more
TL;DR: The antitubercular efficacy of spectinamides demonstrates that synthetic modifications to classical antibiotics can overcome the challenge of intrinsic efflux pump-mediated resistance and expands opportunities for target-based tuberculosis drug discovery.
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A microbiological assessment of novel nitrofuranylamides as anti-tuberculosis agents
Julian G. Hurdle,Robin B. Lee,Nageshwar R. Budha,Elizabeth I. Carson,Jianjun Qi,Michael S. Scherman,Sang-Hyun Cho,Michael R. McNeil,Anne J. Lenaerts,Scott G. Franzblau,Bernd Meibohm,Richard E. Lee +11 more
TL;DR: NFAs have many useful antimycobacterial properties applicable to TB chemotherapy and probably possess a unique mode of action that results in good activity against active and dormant M. tuberculosis.
Journal ArticleDOI
Structural studies of pterin-based inhibitors of dihydropteroate synthase.
Kirk E. Hevener,Mi Kyung Yun,Jianjun Qi,Iain D. Kerr,Kerim Babaoglu,Julian G. Hurdle,Kanya Balakrishna,Stephen W. White,Richard E. Lee +8 more
TL;DR: The structural studies identify the key binding elements and have been used to generate a structure-activity based pharmacophore map that will facilitate the development of the next generation of DHPS inhibitors which specifically target the pterin site.