S
Serena M. Dudek
Researcher at National Institutes of Health
Publications - 89
Citations - 7701
Serena M. Dudek is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Long-term potentiation & Synaptic plasticity. The author has an hindex of 34, co-authored 84 publications receiving 6777 citations. Previous affiliations of Serena M. Dudek include Center for Neural Science & Brown University.
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Journal ArticleDOI
Homosynaptic long-term depression in area CA1 of hippocampus and effects of N-methyl-D-aspartate receptor blockade.
Serena M. Dudek,Mark F. Bear +1 more
TL;DR: The data suggest that synaptic depression can be triggered by prolonged NMDA receptor activation that is below the threshold for inducing synaptic potentiation, and it is proposed that this mechanism is important for the modifications of hippocampal response properties that underlie some forms of learning and memory.
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Cortico-striatal synaptic defects and OCD-like behaviours in Sapap3 -mutant mice
Jeffrey M. Welch,Jing Lu,Ramona M. Rodriguiz,Nicholas C. Trotta,João Peça,Jindong Ding,Catia Feliciano,Meng Chen,J. Paige Adams,Jianhong Luo,Serena M. Dudek,Richard J. Weinberg,Nicole Calakos,William C. Wetsel,Guoping Feng +14 more
TL;DR: It is shown that mice with genetic deletion of Sapap3 exhibit increased anxiety and compulsive grooming behaviour leading to facial hair loss and skin lesions; both behaviours are alleviated by a selective serotonin reuptake inhibitor.
Journal ArticleDOI
Bidirectional long-term modification of synaptic effectiveness in the adult and immature hippocampus.
Serena M. Dudek,Mark F. Bear +1 more
TL;DR: To address the question of whether depressed synapses can still be potentiated and vice versa, LTP was saturated with repeated high- frequency tetani, and then LTD was induced with low-frequency stimulation (LFS), indicating that the same synapses whose transmission had been depressed by LFS were capable of subsequently supporting potentiation.
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Common forms of synaptic plasticity in the hippocampus and neocortex in vitro.
TL;DR: Results provide strong support for the view that common principles may govern experience-dependent synaptic plasticity in CA1 and throughout the superficial layers of the mammalian neocortex.
Journal ArticleDOI
Different Neuronal Activity Patterns Induce Different Gene Expression Programs
Kelsey M. Tyssowski,Nicholas R. DeStefino,Jin-Hyung Cho,Carissa J. Dunn,Robert G. Poston,Crista Carty,Richard D. Jones,Sarah M. Chang,Palmyra Romeo,Mary K. Wurzelmann,James M. Ward,Mark L. Andermann,Ramendra N. Saha,Ramendra N. Saha,Serena M. Dudek,Jesse M. Gray +15 more
TL;DR: The same mechanisms that establish the multi-wave temporal structure of gene induction also enable different gene sets to be induced by different activity durations and improve the understanding of activity-pattern-dependent synaptic plasticity.