R
Richard N. Clayton
Researcher at Keele University
Publications - 118
Citations - 8946
Richard N. Clayton is an academic researcher from Keele University. The author has contributed to research in topics: Loss of heterozygosity & Adenoma. The author has an hindex of 52, co-authored 116 publications receiving 8544 citations. Previous affiliations of Richard N. Clayton include Diabetes Australia & University Hospitals of North Midlands NHS Trust.
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Journal ArticleDOI
Association between premature mortality and hypopituitarism
Jeremy W. Tomlinson,N. Holden,Robert Kerrin Hills,Keith Wheatley,Richard N. Clayton,A. S. Bates,Michael C. Sheppard,Paul M. Stewart +7 more
TL;DR: Age at diagnosis, female sex, and above all, craniopharyngioma were significant independent risk factors and specific endocrine-axis deficiency, with the exception of untreated gonadotropin deficiency, does not seem to have a role.
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The effect of hypopituitarism on life expectancy.
TL;DR: The data confirmed that mortality in patients with hypopituitarism is significantly increased, and the contribution of vascular disease to this poor prognosis was not as great as previously reported, and overall the results favor a multifactorial explanation of the poor long term outcome.
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Growth Hormone and Pituitary Radiotherapy, But Not Serum Insulin-Like Growth Factor-I Concentrations, Predict Excess Mortality in Patients with Acromegaly
TL;DR: It is suggested that reduction of GH levels to less than 2 micro g/liter is beneficial in terms of improving long-term outcome and the sole use of IGF-I as a marker for effective treatment of acromegaly is not justified by this data.
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Corticotropin tests for hypothalamic-pituitary- adrenal insufficiency: a metaanalysis.
Rasa Kazlauskaite,Arthur T. Evans,Carmen V. Villabona,Tariq A. M. Abdu,Bruno Ambrosi,A. Brew Atkinson,Cheung Hei Choi,Richard N. Clayton,C. Hamish Courtney,E. Nazli Gonc,Mohamad Maghnie,Susan R. Rose,Steven Soule,Karen Tordjman +13 more
TL;DR: Low-dose corticotropin test was superior to standard-dose test for diagnosing chronic HPAI, although it has technical limitations.
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Mortality and morbidity in Cushing's disease over 50 years in Stoke-on-Trent, UK: audit and meta-analysis of literature.
TL;DR: Overall mortality in CD is double that of the general population, however, patients with CD in remission fare much better than those with persistence of hypercortisolism, and they appear not to have an increased mortality rate.