Nicholas J. Bond

TL;DR: This work reports that the biological activity of IL-33 at its receptor ST2 is rapidly terminated in the extracellular environment by the formation of two disulphide bridges, resulting in an extensive conformational change that disrupts the ST2 binding site.

TL;DR: NAFLD is associated not only with lipid enrichment, but also with zonal changes of specific lipids and their associated metabolic pathways, which may play a role in the heterogeneous development of NAFLD.

TL;DR: A combination of two mAbs that simultaneously bind to distinct, nonoverlapping epitopes on the spike protein receptor binding domain to neutralize SARS-CoV-2 are described and AZD7442 is projected to contribute to long-term human protection.

TL;DR: MRMaid is a modular tool built around the Genome Annotating Proteomic Pipeline framework, providing a web-based solution with both descriptive and graphical visualizations of transitions, and successfully predicted the peptide and product ion pairs in the majority of cases with appropriate retention time estimates.

TL;DR: It is demonstrated that the signal loss from detector saturation and transmission loss can be deconvoluted by investigation of the peptide isotopic envelope, and methods to minimize these effects on q-TWIMS-TOF instrument are suggested.