R
Richard Seonghun Nho
Researcher at University of Minnesota
Publications - 36
Citations - 2117
Richard Seonghun Nho is an academic researcher from University of Minnesota. The author has contributed to research in topics: Fibroblast & Idiopathic pulmonary fibrosis. The author has an hindex of 22, co-authored 31 publications receiving 1772 citations.
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Journal ArticleDOI
Focal Adhesion Kinase Is Upstream of Phosphatidylinositol 3-Kinase/Akt in Regulating Fibroblast Survival in Response to Contraction of Type I Collagen Matrices via a β1 Integrin Viability Signaling Pathway
TL;DR: A novel role is identified for FAK, functioning upstream of PI3K/Akt, in transducing a β1 integrin viability signal in collagen matrices, and this was associated with diminished Akt activity.
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The ULK1 complex mediates MTORC1 signaling to the autophagy initiation machinery via binding and phosphorylating ATG14
Ji Man Park,Chang Hwa Jung,Minchul Seo,Neil Michael Otto,Douglas Grunwald,Kwan Hyun Kim,Branden S. Moriarity,Young Mi Kim,Colby G. Starker,Richard Seonghun Nho,Daniel F. Voytas,Do Hyung Kim +11 more
TL;DR: A key molecular event is defined for the starvation-induced activation of the ATG14-containing PtdIns3K complex by ULK1, and hierarchical relations between the ULK 1 activation and other autophagy proteins involved in phagophore formation are demonstrated.
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Pathological integrin signaling enhances proliferation of primary lung fibroblasts from patients with idiopathic pulmonary fibrosis
Hong Xia,Deanna Diebold,Richard Seonghun Nho,David M Perlman,Jill Kleidon,Judy Kahm,Svetlana Avdulov,Mark Peterson,John D. Nerva,Peter B. Bitterman,Craig A. Henke +10 more
TL;DR: Results provide direct evidence for defective negative regulation of the proliferative pathway in IPF fibroblasts and support the theory that the pathogenesis of IPF involves an intrinsic fibroblast defect.
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FoxO3a and disease progression.
TL;DR: The function of FoxO3a in disease progression is examined and the potential targets for the treatment of several types of cancers, fibrosis and other types of diseases are discussed.
Journal ArticleDOI
The Role of the Mammalian Target of Rapamycin (mTOR) in Pulmonary Fibrosis.
TL;DR: The pathological role of mTOR kinase in pulmonary fibrosis is discussed and how mTOR inhibitors may mitigate fibrotic progression is examined, to suggest an attractive and unique therapeutic target in lung fibrosis.