Semyon Kruglyak

TL;DR: The HapMap will allow the discovery of sequence variants that affect common disease, will facilitate development of diagnostic tools, and will enhance the ability to choose targets for therapeutic intervention.

TL;DR: A similarity measure that reduces the number of false positives, a new clustering algorithm designed specifically for grouping gene expression patterns, and an interactive graphical cluster analysis tool that allows user feedback and validation are described.

TL;DR: Manta is optimized for rapid germline and somatic analysis, calling structural variants, medium-sized indels and large insertions on standard compute hardware in less than a tenth of the time that comparable methods require to identify only subsets of these variant types.

TL;DR: An integrated SNP genotyping system that combines a highly multiplexed assay with an accurate readout technology based on random arrays of DNA-coated beads is developed that helps enable genome-wide association studies and other large-scale genetic analysis projects.

TL;DR: A simple and efficient algorithm to identify each member of a large collection of DNA-linked objects through the use of hybridization is developed, and it is applied to the manufacture of randomly assembled arrays of beads in wells.