B
Baohong Zhang
Researcher at Biogen Idec
Publications - 70
Citations - 2618
Baohong Zhang is an academic researcher from Biogen Idec. The author has contributed to research in topics: Gene & Computer science. The author has an hindex of 22, co-authored 63 publications receiving 2262 citations. Previous affiliations of Baohong Zhang include Scripps Research Institute & Pfizer.
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Journal ArticleDOI
Highly parallel SNP genotyping.
Jian-Bing Fan,Arnold Oliphant,Richard Shen,Bahram Ghaffarzadeh Kermani,Francisco Garcia,Kevin L. Gunderson,Mark Hansen,Frank J. Steemers,S L Butler,Panagiotis Deloukas,Luana Galver,Sarah E. Hunt,Celeste McBride,Marina Bibikova,Todd Rubano,J Chen,Eliza Wickham,Dennis Doucet,W Chang,D Campbell,Baohong Zhang,Semyon Kruglyak,David Bentley,Jennifer S. Haas,Philippe Rigault,L Zhou,J Stuelpnagel,M S Chee +27 more
TL;DR: An integrated SNP genotyping system that combines a highly multiplexed assay with an accurate readout technology based on random arrays of DNA-coated beads is developed that helps enable genome-wide association studies and other large-scale genetic analysis projects.
Journal ArticleDOI
A Versatile Assay for High-Throughput Gene Expression Profiling on Universal Array Matrices
Jian-Bing Fan,Joanne M. Yeakley,Marina Bibikova,Eugene Chudin,Eliza Wickham,Jing Chen,Dennis Doucet,Philippe Rigault,Baohong Zhang,Richard Shen,Celeste McBride,Hairi Li,Xiang-Dong Fu,Arnold Oliphant,David L. Barker,Mark S. Chee +15 more
TL;DR: A flexible, sensitive, and quantitative gene-expression profiling system for assaying more than 400 genes, with three probes per gene, for 96 samples in parallel, that can cost-effectively profile the expression of hundreds of genes in thousands of samples is reported.
Journal ArticleDOI
Evaluation and comparison of computational tools for RNA-seq isoform quantification.
TL;DR: It is discovered that both sequencing depth and the relative abundance of different isoforms affect quantification accuracy, and this helps data analysts to make informed choice when selecting computational tools for isoform quantification.
Journal ArticleDOI
Evaluation of two main RNA-seq approaches for gene quantification in clinical RNA sequencing: polyA+ selection versus rRNA depletion
TL;DR: It is found that a small number of lncRNAs and small RNAs made up a large fraction of the reads in the rRNA depletion RNA sequencing data, and it is recommended that these RNAs are specifically depleted to improve the sequencing depth of the remaining RNAs.
Journal ArticleDOI
Differential methylation of the TRPA1 promoter in pain sensitivity
Jordana T. Bell,Jordana T. Bell,A K Loomis,Lee M. Butcher,Fei Gao,Baohong Zhang,Craig L. Hyde,Jihua Sun,Honglong Wu,Kirsten J. Ward,Juliette Harris,Serena Scollen,Matthew N. Davies,Leonard C. Schalkwyk,Jonathan Mill,Jonathan Mill,Frances M K Williams,N Li,Panos Deloukas,Panos Deloukas,Panos Deloukas,Stephan Beck,Stephen B. McMahon,Jun Wang,Siby John,Tim D. Spector +25 more
TL;DR: Several pain DMRs show longitudinal stability consistent with susceptibility effects, have similar methylation levels in the brain and altered expression in the skin and may generalize to other complex traits.