R
Richard Tyldesley
Publications - 2
Citations - 2264
Richard Tyldesley is an academic researcher. The author has contributed to research in topics: CMKLR1 & Chemokine receptor. The author has an hindex of 2, co-authored 2 publications receiving 2071 citations.
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The metastasis suppressor gene KiSS-1 encodes kisspeptins, the natural ligands of the orphan G protein-coupled receptor GPR54.
Masato Kotani,Michel Detheux,Ann Vandenbogaerde,David Communi,Jean-Marie Vanderwinden,Emmanuel Le Poul,Stéphane Brézillon,Richard Tyldesley,Nathalie Suarez-Huerta,Fabrice Vandeput,Cédric Blanpain,Serge N. Schiffmann,Gilbert Vassart,Marc Parmentier +13 more
TL;DR: Stimulation of oxytocin secretion after kisspeptin administration to rats confirmed this hypothesis that human GPR54 was highly expressed in placenta, pituitary, pancreas, and spinal cord, suggesting a role in the regulation of endocrine function.
Journal ArticleDOI
Specific recruitment of antigen-presenting cells by chemerin, a novel processed ligand from human inflammatory fluids.
Valérie Wittamer,Jean-Denis Franssen,Marisa Vulcano,Jean François Mirjolet,Emmanuel Le Poul,Isabelle Migeotte,Stéphane Brézillon,Richard Tyldesley,Cédric Blanpain,Michel Detheux,Alberto Mantovani,Alberto Mantovani,Silvano Sozzani,Silvano Sozzani,Gilbert Vassart,Marc Parmentier,David Communi +16 more
TL;DR: Chemerin appears as a potent chemoattractant protein of a novel class, which requires proteolytic activation and is specific for APCs, and was shown to promote calcium mobilization and chemotaxis of immature DCs and macrophages in a ChemR23-dependent manner.