The metastasis suppressor gene KiSS-1 encodes kisspeptins, the natural ligands of the orphan G protein-coupled receptor GPR54.
Masato Kotani,Michel Detheux,Ann Vandenbogaerde,David Communi,Jean-Marie Vanderwinden,Emmanuel Le Poul,Stéphane Brézillon,Richard Tyldesley,Nathalie Suarez-Huerta,Fabrice Vandeput,Cédric Blanpain,Serge N. Schiffmann,Gilbert Vassart,Marc Parmentier +13 more
TLDR
Stimulation of oxytocin secretion after kisspeptin administration to rats confirmed this hypothesis that human GPR54 was highly expressed in placenta, pituitary, pancreas, and spinal cord, suggesting a role in the regulation of endocrine function.About:
This article is published in Journal of Biological Chemistry.The article was published on 2001-09-14 and is currently open access. It has received 1431 citations till now. The article focuses on the topics: Kisspeptins & Oxytocin secretion.read more
Citations
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Journal ArticleDOI
The GPR54 gene as a regulator of puberty
Stephanie B. Seminara,Sophie Messager,Emmanouella E. Chatzidaki,Rosemary R. Thresher,James S. Acierno,Jenna K. Shagoury,Yousef Bo-Abbas,Wendy Kuohung,Kristine M. Schwinof,Alan G. Hendrick,Dirk Zahn,John Dixon,Ursula B. Kaiser,Susan A. Slaugenhaupt,James F. Gusella,Stephen O'Rahilly,Mark Carlton,William F. Crowley,Samuel Aparicio,William H. Colledge +19 more
TL;DR: Puberty is initiated when gonadotropin-releasing hormone begins to be secreted by the hypothalamus, and complementary genetic approaches in humans and mice identified genetic factors that determine the onset of puberty.
Journal ArticleDOI
Hypogonadotropic hypogonadism due to loss of function of the KiSS1-derived peptide receptor GPR54
Nicolas de Roux,Emmanuelle Génin,Jean Claude Carel,Fumihiko Matsuda,Chaussain Jl,Edwin Milgrom +5 more
TL;DR: The present study shows that loss of function of GPR54 is a cause of IHH, and it identifies GPR 54 and possibly KiSS1 protein-derived peptide as playing a major and previously unsuspected role in the physiology of the gonadotropic axis.
Journal ArticleDOI
Functional characterization of human receptors for short chain fatty acids and their role in polymorphonuclear cell activation.
Emmanuel Le Poul,Cecile Loison,Sofie Struyf,Jean-Yves Springael,Vincent Lannoy,Marie-Eve Decobecq,Stéphane Brézillon,Vincent Dupriez,Gilbert Vassart,Jozef Van Damme,Marc Parmentier,Michel Detheux +11 more
TL;DR: The pharmacology of GPR43 matches indeed the effects of SCFAs on neutrophils, in terms of intracellular Ca2+ release and chemotaxis, and might constitute a target allowing us to modulate immune responses in these pathological situations.
Journal ArticleDOI
Kisspeptin directly stimulates gonadotropin-releasing hormone release via G protein-coupled receptor 54
Sophie Messager,Emmanouella E. Chatzidaki,Dan Ma,Alan G. Hendrick,Dirk Zahn,John Dixon,Rosemary R. Thresher,Isabelle Malinge,Didier Lomet,Mark B. L. Carlton,William H. Colledge,Alain Caraty,Samuel Aparicio +12 more
TL;DR: GPR54 is defined as a major control point in the reproductive axis and kisspeptin is suggested to be a neurohormonal effector, demonstrating that a key action ofkisspeptin on the hypothalamo-pituitary-gonadal axis occurs directly at the level of GnRH release.
Journal ArticleDOI
Advances in male contraception.
TL;DR: Great strides have been made in understanding male reproductive physiology; the combined efforts of scientists, clinicians, industry and governmental funding agencies could make an effective, reversible, male contraceptive an option for family planning over the next decade.
References
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Ghrelin is a growth-hormone-releasing acylated peptide from stomach.
TL;DR: The occurrence of ghrelin in both rat and human indicates that GH release from the pituitary may be regulated not only by hypothalamic GHRH, but also by ghrelIn, a peptide specifically releases GH both in vivo and in vitro.
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Orexins and Orexin Receptors: A Family of Hypothalamic Neuropeptides and G Protein-Coupled Receptors that Regulate Feeding Behavior
Takeshi Sakurai,Akira Amemiya,Makoto Ishii,Ichiyo Matsuzaki,Richard M. Chemelli,Hirokazu Tanaka,S. Clay Williams,James A. Richardson,Gerald P. Kozlowski,Shelagh Wilson,Jonathan R.S. Arch,Robin E. Buckingham,Andrea C. Haynes,Steven A. Carr,Roland S. Annan,Dean E. McNulty,Wu Schyong Liu,Jonathan A. Terrett,Nabil Elshourbagy,Derk J. Bergsma,Masashi Yanagisawa +20 more
TL;DR: Two novel neuropeptides are identified, both derived from the same precursor by proteolytic processing, that bind and activate two closely related (previously) orphan G protein-coupled receptors in the hypothalamus of rats.
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Narcolepsy in orexin knockout mice: Molecular genetics of sleep regulation
Richard M. Chemelli,Jon T. Willie,Christopher M. Sinton,Joel K. Elmquist,Thomas E. Scammell,Charlotte E. Lee,James A. Richardson,S. Clay Williams,Yumei Xiong,Yaz Y. Kisanuki,Thomas Fitch,Masamitsu Nakazato,Robert E. Hammer,Clifford B. Saper,Masashi Yanagisawa +14 more
TL;DR: It is proposed that orexin regulates sleep/wakefulness states, and that Orexin knockout mice are a model of human narcolepsy, a disorder characterized primarily by rapid eye movement (REM) sleep dysregulation.
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Isolation and structure of the endogenous agonist of opioid receptor-like ORL1 receptor.
Jean-Claude Meunier,Catherine Mollereau,Lawrence Toll,Lawrence Toll,Charles Suaudeau,Christiane Moisand,Paul Alvinerie,Jean-Luc Butour,Jean-Claude Guillemot,Pascual Ferrara,Bernard Monsarrat,Honoré Mazarguil,Gilbert Vassart,Marc Parmentier,Jean Costentin +14 more
TL;DR: Data indicate that the newly discovered heptadecapeptide is an endogenous agonist of the ORL1 receptor and that it may be endowed with pro-nociceptive properties.
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Orphanin FQ: a neuropeptide that activates an opioidlike G protein-coupled receptor.
Rainer K. Reinscheid,Hans Peter Nothacker,Anne Bourson,Ali Ardati,Robert Henningsen,James R. Bunzow,David K. Grandy,Hanno Langen,Frederick J. Monsma,Olivier Civelli +9 more
TL;DR: Orphanin FQ may act as a transmitter in the brain by modulating nociceptive and locomotor behavior by binding to its receptor in a saturable manner and with high affinity.
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