R
Richard W. Franck
Researcher at Hunter College
Publications - 159
Citations - 4370
Richard W. Franck is an academic researcher from Hunter College. The author has contributed to research in topics: Cycloaddition & Diels–Alder reaction. The author has an hindex of 38, co-authored 159 publications receiving 4208 citations. Previous affiliations of Richard W. Franck include New York University & Fordham University.
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Superior Protection against Malaria and Melanoma Metastases by a C-glycoside Analogue of the Natural Killer T Cell Ligand α-Galactosylceramide
TL;DR: A synthetic C-glycoside analogue of α-GalCer, α-C-galactosylceramide, acts as natural killer T cell ligand in vivo, and stimulates an enhanced Th1-type response in mice, suggesting that α- C- GalCer may one day be an excellent therapeutic option for diseases resolved by Th1 -type responses.
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The C-Glycoside Analogue of the Immunostimulant α-Galactosylceramide (KRN7000): Synthesis and Striking Enhancement of Activity
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The synthesis of 2-deoxyglycosides : 1988-1999
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Glycolipid α-C-galactosylceramide is a distinct inducer of dendritic cell function during innate and adaptive immune responses of mice
Shin-ichiro Fujii,Kanako Shimizu,Hiroaki Hemmi,Mikiko Fukui,Anthony J. Bonito,Guangwu Chen,Richard W. Franck,Moriya Tsuji,Ralph M. Steinman +8 more
TL;DR: The α-C-Galactosylceramide (α-GalCer) is the prototype compound for studying the presentation of glycolipids on CD1d molecules to natural killer T (NKT) lymphocytes.
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Influenza infection in suckling mice expands an NKT cell subset that protects against airway hyperreactivity
Ya-Jen Chang,Hye Young Kim,Lee A. Albacker,Hyun Hee Lee,Nicole Baumgarth,Shizuo Akira,Paul B. Savage,Shin Endo,Takashi Yamamura,J.J. Maaskant,Naoki Kitano,Abel Singh,Apoorva Bhatt,Gurdyal S. Besra,Peter van den Elzen,Ben J. Appelmelk,Richard W. Franck,Guangwu Chen,Rosemarie H. DeKruyff,Michio Shimamura,Michio Shimamura,Petr A. Illarionov,Dale T. Umetsu +22 more
TL;DR: It is shown that infection of suckling mice with influenza A virus protected the mice as adults against allergen-induced airway hyperreactivity (AHR), a cardinal feature of asthma.