Takashi Yamamura

TL;DR: A synthetic glycolipid ligand for CD1d-restricted natural killer T (NKT) cells expressing the semi-invariant T-cell receptor (Vα14+) is preventive against EAE and targeting NKT cells with this ligand may be an attractive means for intervening in human autoimmune diseases such as multiple sclerosis.

TL;DR: Analysis of the bacterial 16S ribosomal RNA (rRNA) gene by using a high-throughput culture-independent pyrosequencing method provided evidence of a moderate dysbiosis in the structure of gut microbiota in patients with MS, and phylogenetic tree analysis revealed that many of the clostridial species associated with MS might be distinct from those broadly associated with autoimmune conditions.

TL;DR: Two waves of gene expression are identified in the quail MBH associated with the initiation of photoinduced secretion of luteinizing hormone and increased TSH in the pars tuberalis seems to trigger long-day photoinduced seasonal breeding.

TL;DR: It is demonstrated that a B-cell subpopulation, exhibiting the CD19intCD27highCD38highCD180− phenotype, is selectively increased in the peripheral blood of NMO patients and that anti-AQP4 antibodies are mainly produced by these cells in the blood of these patients.

TL;DR: It is reported that substituting the C26:0 N-acyl chain of KRN7000 with shorter, unsaturated fatty acids modifies the outcome of Valpha14i NKT cell activation, and one analogue containing a diunsaturated C20 fatty acid potently induced a T helper type 2-biased cytokine response.