Rieko Arakaki

TL;DR: This work reports the finding of novel 14-residue CXCR4 inhibitors, T134 and T140, on the basis of the T22 structure, which showed the highest inhibitory activity against HIV-1 entry and the strongest inhibitory effect on the binding of an anti-CX CR4 monoclonal antibody to CxCR4 among all the CXcr4 inhibitors that have been reported up to now.

TL;DR: Results suggest that Aire regulates the survival of autoreactive T cells beyond transcriptional control of self-protein expression in the thymus, at least against this ubiquitous protein, α-fodrin.

TL;DR: The present study shows that the developmental kinetics and the thymic export of mature thymocytes were undisturbed in adult mice lacking CCR7 or its ligands (CCR7L), and indicates that C CR7-mediated cortex-to-medulla migration of thymocyte migration is essential for establishing central tolerance rather than for supporting the maturation or export ofThymocytes.

TL;DR: Induction of cathepsin S in vivo alters autoantigen presentation and development of organ-specific autoimmunity and is identified as a potential therapeutic strategy for autoimmune disease processes.

TL;DR: It is suggested that haploinsufficiency for FGF10 during a crucial stage of development results in ALSG, and Fgf10+/− mice have a phenotype similar toALSG, providing a model for this disorder.