R
Rizwan Romee
Researcher at Harvard University
Publications - 166
Citations - 5525
Rizwan Romee is an academic researcher from Harvard University. The author has contributed to research in topics: Transplantation & Medicine. The author has an hindex of 27, co-authored 130 publications receiving 3738 citations. Previous affiliations of Rizwan Romee include Brigham and Women's Hospital & University of Minnesota.
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Journal ArticleDOI
TP53 and Decitabine in Acute Myeloid Leukemia and Myelodysplastic Syndromes
John S. Welch,Allegra A. Petti,Christopher A. Miller,Catrina Fronick,Michelle O'Laughlin,Robert S. Fulton,Richard K. Wilson,Jack Baty,Eric J. Duncavage,Bevan Tandon,Yi-Shan Lee,Lukas D. Wartman,Geoffrey L. Uy,Armin Ghobadi,Michael H. Tomasson,Iskra Pusic,Rizwan Romee,Todd A. Fehniger,Keith Stockerl-Goldstein,Ravi Vij,Stephen T. Oh,Camille N. Abboud,Amanda F. Cashen,Mark A. Schroeder,Meagan A. Jacoby,Sharon Heath,Kierstin Luber,Megan Janke,Andrew Hantel,Niloufer Khan,Madina Sukhanova,Randall W. Knoebel,Wendy Stock,Timothy A. Graubert,Matthew J. Walter,Peter Westervelt,Daniel C. Link,John F. DiPersio,Timothy J. Ley +38 more
TL;DR: Patients with AML and MDS who had cytogenetic abnormalities associated with unfavorable risk, TP53 mutations, or both had favorable clinical responses and robust (but incomplete) mutation clearance after receiving serial 10-day courses of decitabine.
Journal ArticleDOI
Cytokine-induced memory-like natural killer cells exhibit enhanced responses against myeloid leukemia
Rizwan Romee,Maximillian Rosario,Melissa M. Berrien-Elliott,Julia A. Wagner,Brea A. Jewell,Timothy Schappe,Jeffrey W. Leong,Sara Abdel-Latif,Stephanie E. Schneider,Sarah Willey,Carly Neal,Liyang Yu,Stephen T. Oh,Yi Shan Lee,Arend Mulder,Frans H.J. Claas,Megan A. Cooper,Todd A. Fehniger +17 more
TL;DR: It is demonstrated that human memory-like NK cells have enhanced interferon-γ production and cytotoxicity against leukemia cell lines or primary human AML blasts in vitro and in mice.
Journal ArticleDOI
Cytokine activation induces human memory-like NK cells.
Rizwan Romee,Stephanie E. Schneider,Jeffrey W. Leong,Julie M Chase,Catherine R. Keppel,Ryan P. Sullivan,Megan A. Cooper,Todd A. Fehniger +7 more
TL;DR: Human NK cells have functional memory-like properties after cytokine activation, which provides a novel rationale for integrating preactivation with combinations of IL-12, IL-15, and IL-18 into NK cell immunotherapy strategies.
Journal ArticleDOI
NK cell CD16 surface expression and function is regulated by a disintegrin and metalloprotease-17 (ADAM17)
Rizwan Romee,Bree Foley,Todd Lenvik,Yue Wang,Bin Zhang,Dave Ankarlo,Xianghua Luo,Sarah Cooley,Michael R. Verneris,Bruce Walcheck,Jeffrey S. Miller +10 more
TL;DR: It is demonstrated that over-activation of ADAM17 in NK cells may be detrimental to their effector functions by down-regulating surface expression of CD16 and CD62L, and an important role for targeting ADam17 to prevent CD16 shedding and improve the efficacy of therapeutic antibodies is supported.
Journal ArticleDOI
First-in-human phase 1 clinical study of the IL-15 superagonist complex ALT-803 to treat relapse after transplantation
Rizwan Romee,Sarah Cooley,Melissa M. Berrien-Elliott,Peter Westervelt,Michael R. Verneris,John E. Wagner,Daniel J. Weisdorf,Bruce R. Blazar,Celalettin Ustun,Todd E. DeFor,Sithara Vivek,Lindsey Peck,John F. DiPersio,Amanda F. Cashen,Rachel L. Kyllo,Amy Musiek,Andras Schaffer,Milan J. Anadkat,Ilana S. Rosman,Daniel D. Miller,Jack O. Egan,Emily K. Jeng,Amy Rock,Hing C. Wong,Todd A. Fehniger,Jeffrey S. Miller +25 more
TL;DR: ALT-803 is a safe, well-tolerated agent that significantly increased NK and CD8+ T cell numbers and function and warrants further investigation to augment antitumor immunity alone and combined with other immunotherapies.