R
Robab Davar
Researcher at Radboud University Nijmegen
Publications - 3
Citations - 407
Robab Davar is an academic researcher from Radboud University Nijmegen. The author has contributed to research in topics: Epigenetics & Epigenomics. The author has an hindex of 2, co-authored 3 publications receiving 281 citations.
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Journal ArticleDOI
β-Glucan Reverses the Epigenetic State of LPS-Induced Immunological Tolerance
Boris Novakovic,Ehsan Habibi,Shuang-Yin Wang,Rob J.W. Arts,Robab Davar,Wout Megchelenbrink,Bowon Kim,Tatyana Kuznetsova,Matthijs Kox,Jelle Zwaag,Filomena Matarese,Simon J. van Heeringen,Eva M. Janssen-Megens,Nilofar Sharifi,Cheng Wang,Farid Keramati,Vivien Schoonenberg,Paul Flicek,Laura Clarke,Peter Pickkers,Simon Heath,Ivo Gut,Mihai G. Netea,Joost H.A. Martens,Colin Logie,Hendrik G. Stunnenberg +25 more
TL;DR: An integrated epigenomic approach is applied to characterize the molecular events involved in LPS-induced tolerance in a time-dependent manner and reveals that tolerance is reversed at the level of distal element histone modification and transcriptional reactivation of otherwise unresponsive genes.
Journal ArticleDOI
Urate-induced epigenetic modifications in myeloid cells.
M. Badii,M. Badii,O. I. Gaal,O. I. Gaal,Maartje C. P. Cleophas,Viola Klück,Robab Davar,Ehsan Habibi,Samuel T. Keating,Boris Novakovic,M. M. A. Helsen,Nicola Dalbeth,Lisa K. Stamp,Donia Macartney-Coxson,Amanda Phipps-Green,Hendrik G. Stunnenberg,Charles A. Dinarello,Charles A. Dinarello,Tony R. Merriman,Tony R. Merriman,Mihai G. Netea,Mihai G. Netea,Tania O. Crişan,Tania O. Crişan,L. A. B. Joosten +24 more
TL;DR: In this article, the authors assessed the epigenetic processes associated to urate-mediated hyper-responsiveness and found that urate exposure primes human monocytes towards a higher capacity to produce and release IL-1β.
Journal ArticleDOI
The alarmin S100A9 hampers osteoclast differentiation from human circulating precursors by reducing the expression of RANK
Irene Di Ceglie,Arjen B. Blom,Robab Davar,Colin Logie,Joost H.A. Martens,Ehsan Habibi,Lisa-Marie Böttcher,Johannes Roth,Thomas Vogl,Carl S. Goodyear,Peter M. van der Kraan,Peter L E M van Lent,Martijn H J van den Bosch +12 more
TL;DR: The data show that S100A9 impedes monocyte‐to‐osteoclast differentiation, probably via a reduction in RANK expression, and hampers osteoclast differentiate from human circulating precursors by reducing the expression of RANK.