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Boris Novakovic
Researcher at University of Melbourne
Publications - 103
Citations - 6230
Boris Novakovic is an academic researcher from University of Melbourne. The author has contributed to research in topics: DNA methylation & Epigenetics. The author has an hindex of 32, co-authored 82 publications receiving 4308 citations. Previous affiliations of Boris Novakovic include Royal Children's Hospital & Radboud University Nijmegen.
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Journal ArticleDOI
BCG Vaccination Protects against Experimental Viral Infection in Humans through the Induction of Cytokines Associated with Trained Immunity
Rob J.W. Arts,Simone J.C.F.M. Moorlag,Boris Novakovic,Yang Li,Shuang-Yin Wang,Marije Oosting,Vinod Kumar,Ramnik J. Xavier,Cisca Wijmenga,Leo A. B. Joosten,Chantal B.E.M. Reusken,Christine Stabell Benn,Christine Stabell Benn,Peter Aaby,Peter Aaby,Marion Koopmans,Hendrik G. Stunnenberg,Reinout van Crevel,Mihai G. Netea,Mihai G. Netea +19 more
TL;DR: BCG vaccination induced genome-wide epigenetic reprograming of monocytes and protected against experimental infection with an attenuated yellow fever virus vaccine strain, with a key role for IL-1β as a mediator of trained immunity responses.
Journal ArticleDOI
Glutaminolysis and Fumarate Accumulation Integrate Immunometabolic and Epigenetic Programs in Trained Immunity.
Rob J.W. Arts,Boris Novakovic,Rob ter Horst,Agostinho Carvalho,Siroon Bekkering,Ekta Lachmandas,Fernando Rodrigues,Ricardo Silvestre,Shih-Chin Cheng,Shih-Chin Cheng,Shuang-Yin Wang,Ehsan Habibi,Luís G. Gonçalves,Inês Mesquita,Cristina Cunha,Arjan van Laarhoven,Frank L. van de Veerdonk,David L. Williams,Jos W. M. van der Meer,Colin Logie,Luke A. J. O'Neill,Charles A. Dinarello,Charles A. Dinarello,Niels P. Riksen,Reinout van Crevel,Clary B. Clish,Richard A. Notebaart,Leo A. B. Joosten,Hendrik G. Stunnenberg,Ramnik J. Xavier,Ramnik J. Xavier,Mihai G. Netea +31 more
TL;DR: Identification of the metabolic pathways leading to induction of trained immunity contributes to the understanding of innate immune memory and opens new therapeutic avenues.
Journal ArticleDOI
Metabolic Induction of Trained Immunity through the Mevalonate Pathway
Siroon Bekkering,Rob J.W. Arts,Boris Novakovic,Ioannis Kourtzelis,Charlotte D C C van der Heijden,Yang Li,Calin D. Popa,Rob ter Horst,Julia van Tuijl,Romana T. Netea-Maier,Frank L. van de Veerdonk,Triantafyllos Chavakis,Leo A. B. Joosten,Jos W. M. van der Meer,Henk Stunnenberg,Niels P. Riksen,Mihai G. Netea,Mihai G. Netea +17 more
TL;DR: It is reported that metabolic signals can induce trained immunity and the role of mevalonate in trained immunity contributes to the understanding of the pathophysiology of HIDS and identifies novel therapeutic targets for clinical conditions with excessive activation of trained immunity.
Journal ArticleDOI
β-Glucan Reverses the Epigenetic State of LPS-Induced Immunological Tolerance
Boris Novakovic,Ehsan Habibi,Shuang-Yin Wang,Rob J.W. Arts,Robab Davar,Wout Megchelenbrink,Bowon Kim,Tatyana Kuznetsova,Matthijs Kox,Jelle Zwaag,Filomena Matarese,Simon J. van Heeringen,Eva M. Janssen-Megens,Nilofar Sharifi,Cheng Wang,Farid Keramati,Vivien Schoonenberg,Paul Flicek,Laura Clarke,Peter Pickkers,Simon Heath,Ivo Gut,Mihai G. Netea,Joost H.A. Martens,Colin Logie,Hendrik G. Stunnenberg +25 more
TL;DR: An integrated epigenomic approach is applied to characterize the molecular events involved in LPS-induced tolerance in a time-dependent manner and reveals that tolerance is reversed at the level of distal element histone modification and transcriptional reactivation of otherwise unresponsive genes.
Journal ArticleDOI
DNA methylation analysis of multiple tissues from newborn twins reveals both genetic and intrauterine components to variation in the human neonatal epigenome
Miina Ollikainen,Katherine R. Smith,Eric Ji Hoon Joo,Hong Kiat Ng,Roberta Andronikos,Boris Novakovic,Nur Khairunnisa Abdul Aziz,John B. Carlin,John B. Carlin,Ruth Morley,Richard Saffery,Jeffrey M. Craig +11 more
TL;DR: The intrauterine period is confirmed as a sensitive time for the establishment of epigenetic variability in humans and an epigenetic mechanism for the previously described phenomenon of 'fetal programming' of disease risk is supported.