K
Kathleen A. Cooney
Researcher at Duke University
Publications - 208
Citations - 16162
Kathleen A. Cooney is an academic researcher from Duke University. The author has contributed to research in topics: Prostate cancer & Cancer. The author has an hindex of 52, co-authored 201 publications receiving 13933 citations. Previous affiliations of Kathleen A. Cooney include United States Department of Veterans Affairs & University of North Carolina at Chapel Hill.
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Journal ArticleDOI
Integrative clinical genomics of advanced prostate cancer
Dan R. Robinson,Eliezer M. Van Allen,Eliezer M. Van Allen,Yi-Mi Wu,Nikolaus Schultz,Robert J. Lonigro,Juan Miguel Mosquera,Bruce Montgomery,Mary-Ellen Taplin,Colin C. Pritchard,Gerhardt Attard,Gerhardt Attard,Himisha Beltran,Wassim Abida,Robert K. Bradley,Jake Vinson,Xuhong Cao,Pankaj Vats,Lakshmi P. Kunju,Maha Hussain,Felix Y. Feng,Scott A. Tomlins,Kathleen A. Cooney,David Smith,Christine Brennan,Javed Siddiqui,Rohit Mehra,Yu Chen,Yu Chen,Dana E. Rathkopf,Dana E. Rathkopf,Michael J. Morris,Michael J. Morris,Stephen B. Solomon,Jeremy C. Durack,Victor E. Reuter,Anuradha Gopalan,Jianjiong Gao,Massimo Loda,Rosina T. Lis,Michaela Bowden,Michaela Bowden,Stephen P. Balk,Glenn C. Gaviola,Carrie Sougnez,Manaswi Gupta,Evan Y. Yu,Elahe A. Mostaghel,Heather H. Cheng,Hyojeong Mulcahy,Lawrence D. True,Stephen R. Plymate,Heidi Dvinge,Roberta Ferraldeschi,Roberta Ferraldeschi,Penny Flohr,Penny Flohr,Susana Miranda,Susana Miranda,Zafeiris Zafeiriou,Zafeiris Zafeiriou,Nina Tunariu,Nina Tunariu,Joaquin Mateo,Joaquin Mateo,Raquel Perez-Lopez,Raquel Perez-Lopez,Francesca Demichelis,Francesca Demichelis,Brian D. Robinson,Marc H. Schiffman,David M. Nanus,Scott T. Tagawa,Alexandros Sigaras,Kenneth Eng,Olivier Elemento,Andrea Sboner,Elisabeth I. Heath,Howard I. Scher,Howard I. Scher,Kenneth J. Pienta,Philip W. Kantoff,Johann S. de Bono,Johann S. de Bono,Mark A. Rubin,Peter S. Nelson,Levi A. Garraway,Levi A. Garraway,Charles L. Sawyers,Arul M. Chinnaiyan +89 more
TL;DR: This cohort study provides clinically actionable information that could impact treatment decisions for affected individuals and identified new genomic alterations in PIK3CA/B, R-spondin, BRAF/RAF1, APC, β-catenin, and ZBTB16/PLZF.
Journal ArticleDOI
REVEL: An Ensemble Method for Predicting the Pathogenicity of Rare Missense Variants
Nilah M. Ioannidis,Joseph H. Rothstein,Joseph H. Rothstein,Vikas Pejaver,Sumit Middha,Shannon K. McDonnell,Saurabh Baheti,Anthony M. Musolf,Qing Li,Emily R. Holzinger,Danielle M. Karyadi,Lisa A. Cannon-Albright,Craig C. Teerlink,Janet L. Stanford,William B. Isaacs,Jianfeng Xu,Kathleen A. Cooney,Kathleen A. Cooney,Ethan M. Lange,Johanna Schleutker,John D. Carpten,Isaac J. Powell,Olivier Cussenot,Geraldine Cancel-Tassin,Graham G. Giles,Graham G. Giles,Robert J. MacInnis,Robert J. MacInnis,Christiane Maier,Chih-Lin Hsieh,Fredrik Wiklund,William J. Catalona,William D. Foulkes,Diptasri Mandal,Rosalind A. Eeles,Zsofia Kote-Jarai,Carlos Bustamante,Daniel J. Schaid,Trevor Hastie,Elaine A. Ostrander,Joan E. Bailey-Wilson,Predrag Radivojac,Stephen N. Thibodeau,Alice S. Whittemore,Weiva Sieh,Weiva Sieh +45 more
TL;DR: This work developed REVEL (rare exome variant ensemble learner), an ensemble method for predicting the pathogenicity of missense variants on the basis of individual tools: MutPred, FATHMM, VEST, PolyPhen, SIFT, PROVEAN, MutationAssessor, LRT, GERP, SiPhy, phyloP, and phastCons.
Journal ArticleDOI
A common variant associated with prostate cancer in European and African populations
Laufey T. Amundadottir,Patrick Sulem,Julius Gudmundsson,Agnar Helgason,Adam Baker,Bjarni A. Agnarsson,Asgeir Sigurdsson,Kristrun R. Benediktsdottir,Jean-Baptiste Cazier,Jesus Sainz,Margret Jakobsdottir,Jelena Kostic,Droplaug N Magnusdottir,Shyamali Ghosh,Kari Agnarsson,Birgitta Birgisdottir,Louise le Roux,Adalheidur Olafsdottir,Thorarinn Blondal,Margret B. Andresdottir,Olafia S Gretarsdottir,Jon Thor Bergthorsson,Daniel F. Gudbjartsson,Arnaldur Gylfason,Gudmar Thorleifsson,Andrei Manolescu,Kristleifur Kristjansson,Gudmundur Geirsson,Helgi J Isaksson,Julie A. Douglas,Jan-Erik Johansson,Katarina Bälter,Fredrik Wiklund,James E. Montie,Xiaoying Yu,Brian K. Suarez,Carole Ober,Kathleen A. Cooney,Henrik Grönberg,William J. Catalona,Gudmundur V. Einarsson,Rosa B. Barkardottir,Jeffrey R. Gulcher,Augustine Kong,Unnur Thorsteinsdottir,Kari Stefansson +45 more
TL;DR: Allele −8 of the microsatellite DG8S737 was associated with prostate cancer in three case-control series of European ancestry from Iceland, Sweden and the US, and the association was replicated in an African American case- control group with a similar OR, leading to a greater estimated PAR.
Journal ArticleDOI
Multiple regions within 8q24 independently affect risk for prostate cancer.
Christopher A. Haiman,Nick Patterson,Matthew L. Freedman,Matthew L. Freedman,Simon Myers,Malcolm C. Pike,Alicja Waliszewska,Alicja Waliszewska,Alicja Waliszewska,Julie Neubauer,Julie Neubauer,Arti Tandon,Arti Tandon,Christine Schirmer,Christine Schirmer,Gavin J. McDonald,Gavin J. McDonald,Steven C. Greenway,Daniel O. Stram,Loic Le Marchand,Laurence N. Kolonel,Melissa A. Frasco,David T.W. Wong,Loreall Pooler,Kristin G. Ardlie,Ingrid Oakley-Girvan,Alice S. Whittemore,Kathleen A. Cooney,Esther M. John,Sue A. Ingles,David Altshuler,Brian E. Henderson,David Reich,David Reich +33 more
TL;DR: Seven prostate cancer risk variants are identified, five of them previously undescribed, spanning 430 kb and each independently predicting risk for prostate cancer (P = 7.9 × 10−19 for the strongest association), and common genotypes that span a more than fivefold range of susceptibility to cancer in some populations are defined.
Journal ArticleDOI
Admixture mapping identifies 8q24 as a prostate cancer risk locus in African-American men
Matthew L. Freedman,Christopher A. Haiman,Nick Patterson,Gavin J. McDonald,Gavin J. McDonald,Arti Tandon,Arti Tandon,Alicja Waliszewska,Alicja Waliszewska,Kathryn L. Penney,Robert G. Steen,Kristin Ardlie,Esther M. John,Esther M. John,Ingrid Oakley-Girvan,Ingrid Oakley-Girvan,Alice S. Whittemore,Kathleen A. Cooney,Sue A. Ingles,David Altshuler,David Altshuler,Brian E. Henderson,David Reich,David Reich +23 more
TL;DR: Admixture mapping indicates a major, still-unidentified risk gene for prostate cancer at 8q24, motivating intense work to find it and finding that the previously described alleles do not explain more than a fraction of the admixture signal.