R
Robert J. Tower
Researcher at Johns Hopkins University
Publications - 55
Citations - 933
Robert J. Tower is an academic researcher from Johns Hopkins University. The author has contributed to research in topics: Mesenchymal stem cell & Stem cell. The author has an hindex of 13, co-authored 40 publications receiving 514 citations. Previous affiliations of Robert J. Tower include Katholieke Universiteit Leuven & University of Kiel.
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Single cell transcriptomics identifies a unique adipose lineage cell population that regulates bone marrow environment
Leilei Zhong,Lutian Yao,Lutian Yao,Robert J. Tower,Yulong Wei,Yulong Wei,Zhen Miao,Jihwan Park,Rojesh Shrestha,Luqiang Wang,Luqiang Wang,Wei Yu,Wei Yu,Nicholas Holdreith,Nicholas Holdreith,Xiaobin Huang,Yejia Zhang,Yejia Zhang,Wei Tong,Wei Tong,Yanqing Gong,Jaimo Ahn,Katalin Susztak,Nathanial Dyment,Mingyao Li,Fanxin Long,Chider Chen,Patrick Seale,Ling Qin +28 more
TL;DR: By employing large scale single cell transcriptome analysis, computationally defined mesenchymal progenitors at different stages and delineated their bi-lineage differentiation paths in young, adult and aging mice, it is concluded that marrow adipogenic lineage precursors are a newly identified component of marrow adipose tissue.
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Vhl deletion in osteoblasts boosts cellular glycolysis and improves global glucose metabolism
Naomi Dirckx,Robert J. Tower,Evi M. Mercken,Roman Vangoitsenhoven,Caroline Moreau-Triby,Tom Breugelmans,Elena Nefyodova,Ruben Cardoen,Chantal Mathieu,Bart Van der Schueren,Cyrille B. Confavreux,Thomas L. Clemens,Thomas L. Clemens,Christa Maes +13 more
TL;DR: Findings reveal a novel link between cellular glucose metabolism in osteoblasts and whole-body glucose homeostasis, controlled by local hypoxia signaling in the skeleton.
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SOX9 keeps growth plates and articular cartilage healthy by inhibiting chondrocyte dedifferentiation/osteoblastic redifferentiation
Abdul Haseeb,Ranjan Kc,Marco Angelozzi,Charles de Charleroy,Danielle Rux,Robert J. Tower,Lutian Yao,Renata Pellegrino da Silva,Maurizio Pacifici,Ling Qin,Véronique Lefebvre +10 more
TL;DR: In this paper, the authors show that SOX9 deficiency prompts growth-plate chondrocytes at all stages to swiftly reach a terminal/dedifferentiated stage marked by expression of Nt5e and Sox4 genes.
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The peroxin Pex34p functions with the Pex11 family of peroxisomal divisional proteins to regulate the peroxisome population in yeast
TL;DR: Pex34p is a novel peroxisomal protein involved in controllingPeroxisome abundance in Saccharomyces cerevisiae and acts to control peroxISome numbers both alone and in cooperation with the Pex11 protein family of peroxIsome divisional proteins.
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Activation of Skeletal Stem and Progenitor Cells for Bone Regeneration Is Driven by PDGFRβ Signaling.
Anna-Marei Böhm,Naomi Dirckx,Robert J. Tower,Nicolas Peredo,Sebastiaan Vanuytven,Koen Theunis,Elena Nefyodova,Ruben Cardoen,Volkhard Lindner,Thierry Voet,Thierry Voet,Matthias Van Hul,Christa Maes +12 more
TL;DR: This work has identified PDGF-PDGFRβ signaling as critical functional mediator of SSPC expansion, migration, and angiotropism during bone repair, and revealed considerable cellular dynamism in the skeletal system.