J
John D. Aitchison
Researcher at Center for Infectious Disease Research and Policy
Publications - 152
Citations - 12535
John D. Aitchison is an academic researcher from Center for Infectious Disease Research and Policy. The author has contributed to research in topics: Nuclear pore & Peroxisome. The author has an hindex of 56, co-authored 139 publications receiving 11480 citations. Previous affiliations of John D. Aitchison include Seattle Children's Research Institute & Howard Hughes Medical Institute.
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Journal ArticleDOI
The Yeast Nuclear Pore Complex: Composition, Architecture, and Transport Mechanism
Michael P. Rout,John D. Aitchison,Adisetyantari Suprapto,Kelly Hjertaas,Yingming Zhao,Brian T. Chait +5 more
TL;DR: In this paper, a comprehensive approach to classify all components of the yeast NPC (nucleoporins) was taken, which involved identifying all the proteins present in a highly enriched NPC fraction, determining which of these proteins were nucleopors, and localizing each nucleoporin within the NPC.
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Pan-viral specificity of IFN-induced genes reveals new roles for cGAS in innate immunity
John W. Schoggins,Donna A. MacDuff,Naoko Imanaka,Maria D. Gainey,Bimmi Shrestha,Jennifer L. Eitson,Katrina B. Mar,R. Blake Richardson,Alexander V. Ratushny,Vladimir Litvak,Rea Dabelic,Balaji Manicassamy,John D. Aitchison,Alan Aderem,Richard M. Elliott,Adolfo García-Sastre,Vincent R. Racaniello,Eric J. Snijder,Wayne M. Yokoyama,Michael S. Diamond,Herbert W. Virgin,Charles M. Rice +21 more
TL;DR: Comparative analysis reveals that the screened ISGs target positive-sense single-stranded RNA viruses more effectively than negative-sensesingle-strander RNA viruses.
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Virtual gating and nuclear transport: the hole picture.
TL;DR: A model, termed 'virtual gating', is suggested to explain the mechanism of this rapid and selective macromolecular trafficking in eukaryotic nucleus.
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Integrative structure and functional anatomy of a nuclear pore complex
Seung Joong Kim,Javier Fernandez-Martinez,Ilona Nudelman,Yi Shi,Wenzhu Zhang,Barak Raveh,Thurston Herricks,Brian D. Slaughter,Joanna A. Hogan,Paula Upla,Ilan E. Chemmama,Riccardo Pellarin,Ignacia Echeverria,Manjunatha Shivaraju,Azraa S. Chaudhury,Junjie Wang,Rosemary Williams,Jay R. Unruh,Charles H. Greenberg,Erica Y. Jacobs,Zhiheng Yu,M. Jason de la Cruz,Roxana Mironska,David L. Stokes,John D. Aitchison,John D. Aitchison,Martin F. Jarrold,Jennifer L. Gerton,Steven J. Ludtke,Christopher W. Akey,Brian T. Chait,Andrej Sali,Michael P. Rout +32 more
TL;DR: The structure of the entire 552-protein nuclear pore complex of the yeast Saccharomyces cerevisiae is determined at sub-nanometre precision by satisfying a wide range of data relating to the molecular arrangement of its constituents.
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Peroxisomes take shape
TL;DR: Ongoing studies are deciphering the diverse molecular mechanisms that underlie biogenesis and how they cooperate to dynamically control peroxisome utility to lead to an understanding of peroxISome dynamics that can be capitalized upon for bioengineering and the development of therapies to improve human health.