R
Robert M. Bryan
Researcher at Baylor College of Medicine
Publications - 107
Citations - 5540
Robert M. Bryan is an academic researcher from Baylor College of Medicine. The author has contributed to research in topics: Cerebral arteries & Endothelium. The author has an hindex of 40, co-authored 103 publications receiving 4545 citations.
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Journal ArticleDOI
Microglial Ramification, Surveillance, and Interleukin-1β Release Are Regulated by the Two-Pore Domain K+ Channel THIK-1
Christian Madry,Christian Madry,Vasiliki Kyrargyri,I. Lorena Arancibia-Carcamo,Renaud Jolivet,Renaud Jolivet,Shinichi Kohsaka,Robert M. Bryan,David Attwell +8 more
TL;DR: It is shown that microglial immune surveillance and cytokine release require THIK-1 channel activity, the main K+ channel expressed in microglia in situ, which is tonically active, and its activity is potentiated by P2Y12 receptors.
Journal ArticleDOI
Alterations in the gut microbiota can elicit hypertension in rats
Sareema Adnan,James W Nelson,Nadim J. Ajami,Venugopal Reddy Venna,Joseph F. Petrosino,Robert M. Bryan,David J. Durgan +6 more
TL;DR: It is concluded that gut dysbiosis can directly affect systolic blood pressure and Manipulation of the gut microbiota may represent an innovative treatment for hypertension.
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Role of the Gut Microbiome in Obstructive Sleep Apnea-Induced Hypertension.
David J. Durgan,Bhanu P. Ganesh,Julia L. Cope,Nadim J. Ajami,Sharon C. Phillips,Joseph F. Petrosino,Emily B. Hollister,Robert M. Bryan +7 more
TL;DR: A causal relationship between gut dysbiosis and hypertension is demonstrated, and manipulation of the microbiota may be a viable treatment for OSA-induced, and possibly other forms of, hypertension.
Journal ArticleDOI
Age-related changes in the gut microbiota influence systemic inflammation and stroke outcome.
Monica S. Spychala,Venugopal Reddy Venna,Michal Jandzinski,Sarah J. Doran,David J. Durgan,Bhanu P. Ganesh,Nadim J. Ajami,Nagireddy Putluri,Joerg Graf,Robert M. Bryan,Louise D. McCullough +10 more
TL;DR: The gut microbiota, or dysbiosis, may be responsible for age-related inflammation and chronic systemic inflammation contributes to the pathogenesis of many age‐related diseases.
Journal ArticleDOI
Endothelial influences on cerebrovascular tone
TL;DR: This review summarizes current knowledge of various dilator and constrictor mechanisms intrinsic to the cerebrovascular endothelium and may participate in neurovascular coupling by conducting local dilations to upstream arteries.