R
Robert S. Du Puy
Researcher at Leiden University Medical Center
Publications - 15
Citations - 576
Robert S. Du Puy is an academic researcher from Leiden University Medical Center. The author has contributed to research in topics: Subclinical infection & Levothyroxine. The author has an hindex of 5, co-authored 11 publications receiving 402 citations. Previous affiliations of Robert S. Du Puy include Leiden University.
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Journal ArticleDOI
Thyroid Hormone Therapy for Older Adults with Subclinical Hypothyroidism.
David J. Stott,Nicolas Rodondi,Patricia M. Kearney,Ian Ford,Rudi G. J. Westendorp,Simon P. Mooijaart,Naveed Sattar,Carole E. Aubert,Drahomir Aujesky,Douglas C. Bauer,Christine Baumgartner,Manuel R. Blum,John Browne,Stephen Byrne,Tinh-Hai Collet,Olaf M. Dekkers,Wendy P. J. den Elzen,Robert S. Du Puy,Graham Ellis,Martin Feller,Carmen Floriani,Kirsty Hendry,Caroline Hurley,J. Wouter Jukema,Sharon Kean,Maria Kelly,Danielle Krebs,Peter Langhorne,Gemma McCarthy,Vera J. C. McCarthy,Alex McConnachie,Mairi McDade,Martina Messow,Anne Marie O'Flynn,David O'Riordan,Rosalinde K. E. Poortvliet,Terence J. Quinn,Audrey Russell,Carol Sinnott,Jan W. A. Smit,H. Anette Van Dorland,Kieran A. Walsh,Elaine Walsh,Torquil Watt,Robbie Wilson,Jacobijn Gussekloo +45 more
TL;DR: Levothyroxine provided no apparent benefits in older persons with subclinical hypothyroidism and there was no significant excess of serious adverse events prespecified as being of special interest.
Journal ArticleDOI
Association Between Levothyroxine Treatment and Thyroid-Related Symptoms Among Adults Aged 80 Years and Older With Subclinical Hypothyroidism.
Simon P. Mooijaart,Robert S. Du Puy,David J. Stott,Patricia M. Kearney,Nicolas Rodondi,Rudi G. J. Westendorp,Wendy P. J. den Elzen,Iris Postmus,Rosalinde K. E. Poortvliet,Diana van Heemst,Barbara C. van Munster,Robin P. Peeters,Ian Ford,Sharon Kean,Claudia-Martina Messow,Manuel R. Blum,Manuel R. Blum,Tinh-Hai Collet,Torquil Watt,Olaf M. Dekkers,J. Wouter Jukema,Johannes W. A. Smit,Peter Langhorne,Jacobijn Gussekloo +23 more
TL;DR: Treatment with levothyroxine, compared with placebo, was not significantly associated with improvement in hypothyroid symptoms or fatigue, and these findings do not support routine use of lev Timothyroxine for treatment of subclinical Hypothyroidism in adults aged 80 years and older.
Journal ArticleDOI
Prevalence of potentially inappropriate prescribing in a subpopulation of older European clinical trial participants: a cross-sectional study
David O Riordan,Carole E. Aubert,Kieran A. Walsh,Anette Van Dorland,Nicolas Rodondi,Robert S. Du Puy,Rosalinde K. E. Poortvliet,Jacobijn Gussekloo,Carol Sinnott,Stephen Byrne,Rose Galvin,J. Wouter Jukema,Simon P. Mooijaart,Christine Baumgartner,Vera J. C. McCarthy,Elaine Walsh,Tinh-Hai Collet,Olaf M. Dekkers,Manuel R. Blum,Patricia M. Kearney +19 more
TL;DR: A significant difference in the prevalence of PIP and PPOs between this cohort of community-dwelling older people is demonstrated and this has important implications for patient safety, healthcare provision and economic costs.
Journal ArticleDOI
Study protocol; Thyroid hormone Replacement for Untreated older adults with Subclinical hypothyroidism - a randomised placebo controlled Trial (TRUST).
David J. Stott,David J. Stott,Jacobijn Gussekloo,Patricia M. Kearney,Nicolas Rodondi,Rudi G. J. Westendorp,Simon P. Mooijaart,Sharon Kean,Terence J. Quinn,Naveed Sattar,Kirsty Hendry,Robert S. Du Puy,Wendy P. J. den Elzen,Rosalinde K. E. Poortvliet,Jan W. A. Smit,J. Wouter Jukema,Olaf M. Dekkers,Manuel R. Blum,Tinh-Hai Collet,Vera J. C. McCarthy,Caroline Hurley,Stephen Byrne,John Browne,Torquil Watt,Douglas C. Bauer,Ian Ford +25 more
TL;DR: This large multicentre RCT of levothyroxine treatment of subclinical hypothyroidism is powered to detect clinically relevant change in symptoms / quality of life and is likely to be highly influential in guiding treatment of this common condition.
Journal ArticleDOI
The Relation Between Thyroid Function and Anemia: A Pooled Analysis of Individual Participant Data.
Daisy M. Wopereis,Robert S. Du Puy,Diana van Heemst,John P. Walsh,John P. Walsh,Alexandra Bremner,Stephan J. L. Bakker,Douglas C. Bauer,Anne R. Cappola,Graziano Ceresini,Jean Degryse,Jean Degryse,Robin P. F. Dullaart,Martin Feller,Luigi Ferrucci,Carmen Floriani,Oscar H. Franco,Massimo Iacoviello,Georgio Iervasi,Misa Imaizumi,J. Wouter Jukema,Kay-Tee Khaw,Robert Luben,Sabrina Molinaro,Matthias Nauck,Kushang V. Patel,Robin P. Peeters,Bruce M. Psaty,Bruce M. Psaty,Salman Razvi,Roger K. Schindhelm,Natasja M. van Schoor,David J. Stott,Bert Vaes,Bert Vaes,Mark Vanderpump,Henry Völzke,Rudi G. J. Westendorp,Nicolas Rodondi,Christa M. Cobbaert,Jacobijn Gussekloo,Wendy P. J. den Elzen +41 more
TL;DR: Higher odds of having anemia were observed in participants with both hypothyroid function and hyperthyroid function, and reduced thyroid function at baseline showed a trend of increased risk of developing anemia during follow-up.