Hox genes in vertebrate development.

Protein tyrosine kinases (PTKs) regulate cell proliferation, cell differentiation, and signaling processes in the cells of the immune system. Uncontrolled signaling from receptor tyrosine kinases and intracellular tyrosine kinases can lead to inflammatory responses and to diseases such as cancer, atherosclerosis, and psoriasis. Thus, inhibitors that block the activity of tyrosine kinases and the signaling pathways they activate may provide a useful basis for drug development. This article summarizes recent progress in the development of PTK inhibitors and demonstrates their potential use in the treatment of disease.

https://science.sciencemag.org/content/sci/267/5205/1782.full.pdf

Tyrosine kinase inhibition: an approach to drug development

Tyrosine Kinase Inhibition: AnApproach toDrug Development

https://www.cell.com/cell/pdf/0092-8674(93)90414-L.pdf

JAK2 associates with the erythropoietin receptor and is tyrosine phosphorylated and activated following stimulation with erythropoietin

▪ Abstract Tyrosine phosphorylation is one of the key covalent modifications that occurs in multicellular organisms as a result of intercellular communication during embryogenesis and maintenance o...

Robert S. Sparkes

Papers

Deficient expression of a B cell cytoplasmic tyrosine kinase in human X-linked agammaglobulinemia