D
Douglas C. Saffran
Researcher at University of California, Los Angeles
Publications - 57
Citations - 3786
Douglas C. Saffran is an academic researcher from University of California, Los Angeles. The author has contributed to research in topics: Prostate cancer & Prostate. The author has an hindex of 16, co-authored 50 publications receiving 3621 citations.
Papers
More filters
Journal ArticleDOI
Deficient expression of a B cell cytoplasmic tyrosine kinase in human X-linked agammaglobulinemia
Satoshi Tsukada,Douglas C. Saffran,David J. Rawlings,Ornella Parolini,Ornella Parolini,R. Cutler Allen,Ivana Klisak,Robert S. Sparkes,Hiromi Kubagawa,Hiromi Kubagawa,Hiromi Kubagawa,T. K. Mohandas,Shirley G. Quan,John W. Belmont,Max D. Cooper,Max D. Cooper,Max D. Cooper,Mary Ellen Conley,Mary Ellen Conley,Owen N. Witte +19 more
TL;DR: A novel cytoplasmic tyrosine kinase, termed BPK (B cell progenitor kinase), which is expressed in all stages of the B lineage and in myeloid cells is described, likely the XLA gene and functions in pathways critical to B cell expansion.
Journal ArticleDOI
Mutation of unique region of Bruton's tyrosine kinase in immunodeficient XID mice
David J. Rawlings,Douglas C. Saffran,Satoshi Tsukada,David A. Largaespada,J. Christopher Grimaldi,Lucie Cohen,Randolph N. Mohr,J. Fernando Bazan,Maureen C. Howard,Neal G. Copeland,Nancy A. Jenkins,Owen N. Witte +11 more
TL;DR: The Btk gene, btk, was mapped to the xid region of the mouse X chromosome by interspecific backcross analysis and a single conserved residue within the amino terminal unique region of Btk was mutated in XID mice, probably interferes with normal B cell signaling mediated by Btk protein interactions.
Journal ArticleDOI
STEAP: a prostate-specific cell-surface antigen highly expressed in human prostate tumors.
Rene S. Hubert,Igor Vivanco,Emily I. Chen,Shiva Rastegar,Kahan Leong,Steve Chappell Mitchell,Rashida Madraswala,Yanhong Zhou,James Kuo,Arthur B. Raitano,Aya Jakobovits,Douglas C. Saffran,Daniel E. H. Afar +12 more
TL;DR: The results support STEAP as a cell-surface tumor-antigen target for prostate cancer therapy and diagnostic imaging and support its role as a channel or transporter protein.
Journal ArticleDOI
Alternative signals to RAS for hematopoietic transformation by the BCR-ABL oncogene
TL;DR: In vivo tests of malignant potential reveal a most critical role for signals dependent on the BCR-ABL SH2 domain, which is strongly affected by increased dosage of the SHC adapter protein, which can connect tyrosine kinase signals to RAS.
Journal Article
Catalytic cleavage of the androgen-regulated TMPRSS2 protease results in its secretion by prostate and prostate cancer epithelia.
Daniel E. H. Afar,Igor Vivanco,Rene S. Hubert,James Kuo,Emily I. Chen,Douglas C. Saffran,Arthur B. Raitano,Aya Jakobovits +7 more
TL;DR: Immunohistochemical analysis of clinical specimens and specific monoclonal antibodies demonstrate that TMPRSS2 is a secreted protease that is highly expressed in prostate and prostate cancer, making it a potential target for cancer therapy and diagnosis.