R
Robert Strome
Researcher at University of Toronto
Publications - 12
Citations - 4423
Robert Strome is an academic researcher from University of Toronto. The author has contributed to research in topics: Presenilin & Wild type. The author has an hindex of 10, co-authored 12 publications receiving 4275 citations.
Papers
More filters
Journal ArticleDOI
Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid β-protein in both transfected cells and transgenic mice
Martin Citron,David Westaway,Weiming Xia,George A. Carlson,Thekla S. Diehl,G. Levesque,Kelly Johnson-Wood,Michael K. Lee,Peter Seubert,Angela Davis,Dora Kholodenko,Ruth Motter,R. Sherrington,Billie J. Perry,Hong Yao,Robert Strome,Ivan Lieberburg,Johanna M. Rommens,Soyeon Kim,Dale Schenk,Paul E. Fraser,Peter St. George Hyslop,Dennis J. Selkoe +22 more
TL;DR: The data demonstrate that the preseniiin mutations cause a dominant gain of function and may induce AD by enhancing Aβ42 production, thus promoting cerebral β-amyloidosis.
Journal ArticleDOI
The cellular prion protein binds copper in vivo
David R. Brown,Kefeng Qin,Jochen Herms,Axel Madlung,Jean Manson,Robert Strome,Paul E. Fraser,T. P. A. Kruck,A von Bohlen,Walter J. Schulz-Schaeffer,Armin Giese,David Westaway,Hans A. Kretzschmar +12 more
TL;DR: Findings indicate that PrPC can exist in a Cu-metalloprotein form in vivo, and that its amino terminus contains the octapeptide PHGGGWGQ, which is among the best-preserved regions of mammalian PrPC.
Journal ArticleDOI
Early-onset Amyloid Deposition and Cognitive Deficits in Transgenic Mice Expressing a Double Mutant Form of Amyloid Precursor Protein 695
M. Azhar Chishti,Dun-Shen Yang,Christopher Janus,Amie L. Phinney,Patrick Horne,Jacqueline Pearson,Robert Strome,Noah Zuker,James E. Loukides,Janet French,Sherry Turner,Gianluca Lozza,Mariagrazia Grilli,Suzanne Kunicki,Céline Morissette,Julie Paquette,Francine Gervais,Catherine Bergeron,Paul E. Fraser,George A. Carlson,Peter St George-Hyslop,David Westaway +21 more
TL;DR: High level production of the pathogenic Aβ42 form of Aβ peptide was associated with an early impairment in TgCRND8 mice in acquisition and learning reversal in the reference memory version of the Morris water maze, present by 3 months of age.
Journal ArticleDOI
Ataxia in prion protein (PrP)-deficient mice is associated with upregulation of the novel PrP-like protein doppel.
Richard C. Moore,Inyoul Lee,Gregory L. Silverman,Paul M. Harrison,Robert Strome,Cornelia Heinrich,A. Karunaratne,Stephen H. Pasternak,M A Chishti,Yan Liang,Peter Mastrangelo,Kai Wang,Arian Fa Smit,S. Katamine,George A. Carlson,Fred E. Cohen,Stanley B. Prusiner,D. W. Melton,Patrick Tremblay,Leroy Hood,David Westaway +20 more
TL;DR: Dpl is the first PrP-like protein to be described in mammals, and since Dpl seems to cause neurodegeneration similar to PrP, the linked expression of the Prnp and Prnd genes may play a previously unrecognized role in the pathogenesis of prion diseases or other illnesses.
Journal ArticleDOI
Spatial learning in transgenic mice expressing human presenilin 1 (PS1) transgenes.
Christopher Janus,S D’Amelio,O Amitay,M A Chishti,Robert Strome,Paul E. Fraser,George A. Carlson,John C. Roder,P H St George Hyslop,David Westaway +9 more
TL;DR: The lack of progressive spatial learning impairment in mice expressing the mutated human PS1 transgene in the WM does not preclude impairments in other cognitive tasks but suggests that full phenotypic expression of mutant PS1 alleles may require co-expression of human versions of other AD-associated genes.