Sherry Turner

TL;DR: High level production of the pathogenic Aβ42 form of Aβ peptide was associated with an early impairment in TgCRND8 mice in acquisition and learning reversal in the reference memory version of the Morris water maze, present by 3 months of age.

TL;DR: It is found that transgenic mice overexpressing APP have a profound and selective impairment in endothelium–dependent regulation of the neocortical microcirculation, which may contribute to the alterations in cerebral blood flow and to neuronal dysfunction in Alzheimer's dementia.

TL;DR: Transgenic mice overexpressing APP and Abeta have a profound attenuation in the increase in neocortical blood flow elicited by somatosensory activation, which indicates a potentially deleterious mismatch between substrate delivery and energy demands imposed by neural activity.

TL;DR: Differential survival does not appear to reflect genetic differences in APP processing, but rather host responses to APP or its derivatives, and FGF2 transgene overexpression enhances the lethal effects of APP.

TL;DR: To understand better the physiology and expression of PrPC, mouse PrP gene (Prn-p) was retrieved from yeast artificial chromosome (YAC), cosmid, phage, and cDNA clones to find conserved motifs which may represent binding sites for as yet unidentified transcription factors.