R
Roberto Díez-Martínez
Researcher at Spanish National Research Council
Publications - 16
Citations - 710
Roberto Díez-Martínez is an academic researcher from Spanish National Research Council. The author has contributed to research in topics: Streptococcus pneumoniae & Lysin. The author has an hindex of 11, co-authored 16 publications receiving 534 citations. Previous affiliations of Roberto Díez-Martínez include Carlos III Health Institute.
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Journal ArticleDOI
Novel Phage Lysin Capable of Killing the Multidrug-Resistant Gram-Negative Bacterium Acinetobacter baumannii in a Mouse Bacteremia Model
Rolf Lood,Benjamin Y. Winer,Adam J. Pelzek,Roberto Díez-Martínez,Mya Thandar,Chad W. Euler,Raymond Schuch,Vincent A. Fischetti +7 more
TL;DR: PlyF307 represents the first highly active therapeutic lysin specific for Gram-negative organisms in an array of native lysins found in Acinetobacter phage and rescued mice from lethal A. baumannii bacteremia.
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Zebrafish: Speeding Up the Cancer Drug Discovery Process
TL;DR: This review provides a comprehensive overview of zebrafish in the cancer drug discovery process, from approaches to induce malignant tumors, techniques to monitor cancer progression, and strategies for compound administration to a compilation of the 355 existing case studies showing the impact ofZebrafish models on cancer drug Discovery.
Journal ArticleDOI
A novel chimeric phage lysin with high in vitro and in vivo bactericidal activity against Streptococcus pneumoniae
Roberto Díez-Martínez,Héctor D. de Paz,Esther García-Fernández,Noemí Bustamante,Chad W. Euler,Vincent A. Fischetti,Margarita Menéndez,Pedro García +7 more
TL;DR: Cpl-711, the most powerful endolysin against pneumococci, offers a promising therapeutic perspective for the treatment of multiresistant pneumococcal infections and domain swapping among phage lysins allows the construction of new chimeric enzymes with high bactericidal activity and a different substrate range.
Journal ArticleDOI
Improving the Lethal Effect of Cpl-7, a Pneumococcal Phage Lysozyme with Broad Bactericidal Activity, by Inverting the Net Charge of Its Cell Wall-Binding Module
Roberto Díez-Martínez,Héctor D. de Paz,Noemí Bustamante,Ernesto García,Margarita Menéndez,Pedro García +5 more
TL;DR: These findings provide a strategy to improve the lytic activity of phage endolysins based on facilitating their pass through the negatively charged bacterial envelope, and thereby their interaction with the cell wall target, by modulating the net charge of thecell wall-binding modules.
Journal ArticleDOI
Auranofin efficacy against MDR Streptococcus pneumoniae and Staphylococcus aureus infections
Leire Aguinagalde,Roberto Díez-Martínez,Jose Yuste,Inmaculada Royo,Carmen Gil,Iñigo Lasa,Mar Martín-Fontecha,Nagore I. Marín-Ramos,Carmen Ardanuy,Josefina Liñares,Pedro García,Ernesto García,José María Sánchez-Puelles +12 more
TL;DR: The clinical management of auranofin, alone or in combination with other antibiotics, deserves further exploration before use in patients presenting therapeutic failure caused by infections with multiresistant Gram-positive pathogens.