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Benjamin Y. Winer
Researcher at Princeton University
Publications - 30
Citations - 1020
Benjamin Y. Winer is an academic researcher from Princeton University. The author has contributed to research in topics: Hepatitis B virus & Virus. The author has an hindex of 16, co-authored 25 publications receiving 826 citations. Previous affiliations of Benjamin Y. Winer include Johns Hopkins University & University of Washington.
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Journal ArticleDOI
Broadly neutralizing antibodies abrogate established hepatitis C virus infection
Ype P. de Jong,Ype P. de Jong,Marcus Dorner,Michiel C. Mommersteeg,Jing W. Xiao,Alejandro B. Balazs,Justin B. Robbins,Benjamin Y. Winer,Sherif Gerges,Kevin Vega,Rachael N. Labitt,Bridget M. Donovan,Erick Giang,Anuradha Krishnan,Luis Chiriboga,Michael Charlton,Dennis R. Burton,Dennis R. Burton,David Baltimore,Mansun Law,Charles M. Rice,Alexander Ploss,Alexander Ploss +22 more
TL;DR: It is demonstrated that three broadly nAbs—AR3A, AR3B, and AR4A—delivered with adeno-associated viral vectors can confer protection against viral challenge in humanized mice and can abrogate an ongoing HCV infection in primary hepatocyte cultures and in a human liver chimeric mouse model.
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Novel Phage Lysin Capable of Killing the Multidrug-Resistant Gram-Negative Bacterium Acinetobacter baumannii in a Mouse Bacteremia Model
Rolf Lood,Benjamin Y. Winer,Adam J. Pelzek,Roberto Díez-Martínez,Mya Thandar,Chad W. Euler,Raymond Schuch,Vincent A. Fischetti +7 more
TL;DR: PlyF307 represents the first highly active therapeutic lysin specific for Gram-negative organisms in an array of native lysins found in Acinetobacter phage and rescued mice from lethal A. baumannii bacteremia.
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Novel Engineered Peptides of a Phage Lysin as Effective Antimicrobials against Multidrug-Resistant Acinetobacter baumannii.
Mya Thandar,Rolf Lood,Benjamin Y. Winer,Douglas R. Deutsch,Chad W. Euler,Vincent A. Fischetti +5 more
TL;DR: The prospect of using peptide derivatives from bacteriophage lysins to treat topical infections and remove biofilms caused by Gram-negative pathogens is demonstrated.
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Long-term hepatitis B infection in a scalable hepatic co-culture system.
Benjamin Y. Winer,Tiffany Huang,Eitan Pludwinski,Brigitte Heller,Felix Wojcik,Gabriel Lipkowitz,Amit Parekh,Cheul H. Cho,Anil B. Shrirao,Tom W. Muir,Eric Novik,Alexander Ploss +11 more
TL;DR: It is shown that cell-culture and patient-derived hepatitis B virus can establish persistent infection for over 30 days in a self-assembling, primary hepatocyte co-culture system and that infection can be established without antiviral immune suppression, and susceptibility is not donor dependent.
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Selective expansion of myeloid and NK cells in humanized mice yields human-like vaccine responses
Florian Douam,Carly G. K. Ziegler,Gabriela Hrebikova,Bruno Fant,Robert W. Leach,Lance Parsons,Wei Wang,Jenna M. Gaska,Benjamin Y. Winer,Brigitte Heller,Alex K. Shalek,Alexander Ploss +11 more
TL;DR: It is demonstrated that selective expansion of human myeloid and natural killer cells promotes transcriptomic responses akin to those of human vaccinees and correlates with the development of an antigen-specific cellular and humoral response to YFV-17D.