C
Christina G. Kane
Researcher at Harvard University
Publications - 4
Citations - 2456
Christina G. Kane is an academic researcher from Harvard University. The author has contributed to research in topics: Dendritic spine & Dendritic spine morphogenesis. The author has an hindex of 4, co-authored 4 publications receiving 2329 citations. Previous affiliations of Christina G. Kane include Boston Children's Hospital.
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Journal ArticleDOI
A brain-specific microRNA regulates dendritic spine development
Gerhard Schratt,Fabian Tuebing,Elizabeth A. Nigh,Elizabeth A. Nigh,Christina G. Kane,Christina G. Kane,Mary E. Sabatini,Michael A. Kiebler,Michael E. Greenberg,Michael E. Greenberg +9 more
TL;DR: It is shown that a brain-specific microRNA, miR-134>, is localized to the synapto-dendritic compartment of rat hippocampal neurons and negatively regulates the size of dendritic spines—postsynaptic sites of excitatory synaptic transmission.
Journal ArticleDOI
A functional screen implicates microRNA-138-dependent regulation of the depalmitoylation enzyme APT1 in dendritic spine morphogenesis
Gabriele Siegel,Gregor Obernosterer,Roberto Fiore,Martin Oehmen,Silvia Bicker,Mette Christensen,Mette Christensen,Sharof Khudayberdiev,Philipp F Leuschner,Clara J L Busch,Christina G. Kane,Katja Hübel,Frank J. Dekker,Christian Hedberg,Balamurugan Rengarajan,Carsten Drepper,Carsten Drepper,Herbert Waldmann,Sakari Kauppinen,Sakari Kauppinen,Michael E. Greenberg,Andreas Draguhn,Marc Rehmsmeier,Marc Rehmsmeier,Javier Martinez,Gerhard Schratt +25 more
TL;DR: The results uncover a previously unknown miRNA-dependent mechanism in neurons and demonstrate a previously unrecognized complexity of mi RNA-dependent control of dendritic spine morphogenesis.
Journal ArticleDOI
The Rac1 guanine nucleotide exchange factor Tiam1 mediates EphB receptor-dependent dendritic spine development
Kimberley F. Tolias,Jay B. Bikoff,Christina G. Kane,Christos S. Tolias,Linda Hu,Michael E. Greenberg +5 more
TL;DR: It is reported that the Rac1 guanine nucleotide exchange factor Tiam1 interacts with the EphB2 receptor in a kinase-dependent manner and can then promote Rac1-dependent actin cytoskeletal remodeling required for dendritic spine morphogenesis.
Journal ArticleDOI
Corrigendum: A brain-specific microRNA regulates dendritic spine development
Gerhard Schratt,Fabian Tuebing,Elizabeth A. Nigh,Christina G. Kane,Mary E. Sabatini,Michael A. Kiebler,Michael E. Greenberg +6 more
TL;DR: This corrects the article to show that the Higgs boson bacterium is a prokaryotic substance, not a “spatially aggregating substance” as previously reported, which can be a source of infection for other animals.