R
Rodolfo Marquez
Researcher at University of Glasgow
Publications - 94
Citations - 2838
Rodolfo Marquez is an academic researcher from University of Glasgow. The author has contributed to research in topics: Biomimetic synthesis & Total synthesis. The author has an hindex of 24, co-authored 93 publications receiving 2671 citations. Previous affiliations of Rodolfo Marquez include University of Oxford & University of Canterbury.
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Journal ArticleDOI
Role that phosphorylation of GSK3 plays in insulin and Wnt signalling defined by knockin analysis
Edward J. McManus,Kei Sakamoto,Laura J. Armit,Leah Ronaldson,Natalia Shpiro,Rodolfo Marquez,Dario R. Alessi +6 more
TL;DR: The function of Ser21/Ser9 phosphorylation in several processes in which GSK3 inactivation has previously been implicated is established, as judged by the stabilisation of β‐catenin and stimulation of Wnt‐dependent transcription.
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BIRB796 inhibits all p38 MAPK isoforms in vitro and in vivo.
TL;DR: The compound BIRB796 also inhibits the activity and activation of SAPK3/p38γ as discussed by the authors, which is a physiological substrate of p38α and p38β.
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The Mnks are novel components in the control of TNF alpha biosynthesis and phosphorylate and regulate hnRNP A1.
Maria Buxadé,Josep Lluis Parra,Simon Rousseau,Natalia Shpiro,Rodolfo Marquez,Nick Morrice,Jenny Bain,Enric Espel,Christopher G. Proud +8 more
TL;DR: Mnks are novel players in cytokine regulation and potential new targets for anti-inflammatory therapy after being identified as ARE binding proteins that are Mnk substrates, such as hnRNP A1, which they phosphorylate at two sites in vitro.
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Total Synthesis of the Callipeltoside Aglycon.
TL;DR: Key steps in the preparation of macrolide precursor 1 include a boron-mediated anti-aldol coupling in tandem with Yamamoto's vinylogous aldol reaction (A) and TES=triethylsilyl.
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VX-680 inhibits Aurora A and Aurora B kinase activity in human cells.
TL;DR: In cells, VX-680 blocks mitotic Histone H3 phosphorylation and induces polyploidy and apoptosis, consistent with inhibition of the mitotic protein kinase Aurora B, and is identified as dual intracellular targets of Aurora A and Aurora B.