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Rodrigo R.R. Duarte
Researcher at Cornell University
Publications - 30
Citations - 370
Rodrigo R.R. Duarte is an academic researcher from Cornell University. The author has contributed to research in topics: Gene & Neurogenesis. The author has an hindex of 8, co-authored 28 publications receiving 215 citations. Previous affiliations of Rodrigo R.R. Duarte include University of Cambridge & King's College London.
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Journal ArticleDOI
Psychosis Risk Candidate ZNF804A Localizes to Synapses and Regulates Neurite Formation and Dendritic Spine Structure.
P J Michael Deans,Pooja Raval,Katherine J. Sellers,Nicholas J.F. Gatford,Sanjay Halai,Rodrigo R.R. Duarte,Carole Shum,Katherine Warre-Cornish,Victoria E. Kaplun,Graham Cocks,Matthew Hill,Nicholas John Bray,Jack Price,Deepak Srivastava +13 more
TL;DR: A novel subcellular distribution for ZNF804A within somatodendritic compartments and a nanoscopic organization at excitatory synapses is revealed, suggesting that ZNF805A plays an active role in neurite formation, maintenance of dendritic spines, and activity-dependent structural plasticity.
Journal ArticleDOI
Interferon-γ signaling in human iPSC-derived neurons recapitulates neurodevelopmental disorder phenotypes.
Katherine Warre-Cornish,Leo W. Perfect,Roland Nagy,Rodrigo R.R. Duarte,Rodrigo R.R. Duarte,Matthew J. Reid,Pooja Raval,Annett Mueller,Amanda L. Evans,Amalie Couch,Cedric Ghevaert,Grainne M. McAlonan,Eva Loth,Declan G. Murphy,Timothy R. Powell,Timothy R. Powell,Anthony C. Vernon,Deepak Srivastava,Jack Price,Jack Price +19 more
TL;DR: RNA sequencing analysis revealed that major histocompatibility complex class I genes were persistently up-regulated through neuronal differentiation—an effect that was mediated by IFN-γ-induced promyelocytic leukemia protein (PML) nuclear bodies, suggesting convergence between genetic and environmental risk factors.
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Genome‐wide significant schizophrenia risk variation on chromosome 10q24 is associated with altered cis‐regulation of BORCS7, AS3MT, and NT5C2 in the human brain
Rodrigo R.R. Duarte,Claire Troakes,Matthew Nolan,Deepak Srivastava,Robin M. Murray,Nicholas John Bray,Nicholas John Bray +6 more
TL;DR: This study implicates altered neural expression of BORCS7, AS3MT, and NT5C2 in susceptibility to schizophrenia arising from genetic variation at the chromosome 10q24 locus.
Journal ArticleDOI
The polygenic nature of telomere length and the anti-ageing properties of lithium
Fiona Coutts,Alish B. Palmos,Rodrigo R.R. Duarte,Rodrigo R.R. Duarte,Simone de Jong,Cathryn M. Lewis,Cathryn M. Lewis,Danai Dima,Danai Dima,Timothy R. Powell +9 more
TL;DR: A potential use of polygenic risk scoring for the prediction of adult telomere length and consequently lithium’s anti-ageing efficacy is indicated.
Journal ArticleDOI
The Psychiatric Risk Gene NT5C2 Regulates Adenosine Monophosphate-Activated Protein Kinase Signaling and Protein Translation in Human Neural Progenitor Cells.
Rodrigo R.R. Duarte,Nathaniel D. Bachtel,Marie-Caroline Cotel,Sang Hyuck Lee,Sashika Selvackadunco,Iain A. Watson,Gary A. Hovsepian,Claire Troakes,Gerome Breen,Douglas F. Nixon,Robin M. Murray,Nicholas John Bray,Ioannis Eleftherianos,Anthony C. Vernon,Timothy R. Powell,Deepak Srivastava +15 more
TL;DR: An extensive neurobiological characterization of the psychiatric risk gene NT5C2 is provided, describing its previously unknown role in the regulation of AMPK signaling and protein translation in neural stem cells and its association with Drosophila melanogaster motility behavior.