Genome‐wide significant schizophrenia risk variation on chromosome 10q24 is associated with altered cis‐regulation of BORCS7, AS3MT, and NT5C2 in the human brain
Rodrigo R.R. Duarte,Claire Troakes,Matthew Nolan,Deepak Srivastava,Robin M. Murray,Nicholas John Bray,Nicholas John Bray +6 more
TLDR
This study implicates altered neural expression of BORCS7, AS3MT, and NT5C2 in susceptibility to schizophrenia arising from genetic variation at the chromosome 10q24 locus.Abstract:
Chromosome 10q24.32-q24.33 is one of the most robustly supported risk loci to emerge from genome-wide association studies (GWAS) of schizophrenia. However, extensive linkage disequilibrium makes it difficult to distinguish the actual susceptibility gene(s) at the locus, limiting its value for improving biological understanding of the condition. In the absence of coding changes that can account for the association, risk is likely conferred by altered regulation of one or more genes in the region. We, therefore, used highly sensitive measures of allele-specific expression to assess cis-regulatory effects associated with the two best-supported schizophrenia risk variants (SNP rs11191419 and indel ch10_104957618_I/rs202213518) on the primary positional candidates BORCS7, AS3MT, CNNM2, and NT5C2 in the human brain. Heterozygosity at rs11191419 was associated with increased allelic expression of BORCS7 and AS3MT in the fetal and adult brain, and with reduced allelic expression of NT5C2 in the adult brain. Heterozygosity at ch10_104957618_I was associated with reduced allelic expression of NT5C2 in both the fetal and adult brain. Comparisons between cDNA ratios in heterozygotes and homozygotes for the risk alleles indicated that cis-effects on NT5C2 expression in the adult dorsolateral prefrontal cortex could be largely accounted for by genotype at these two risk variants. While not excluding effects on other genes in the region, this study implicates altered neural expression of BORCS7, AS3MT, and NT5C2 in susceptibility to schizophrenia arising from genetic variation at the chromosome 10q24 locus. © 2016 The Authors. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics Published by Wiley Periodicals, Inc.read more
Citations
More filters
Journal ArticleDOI
The genetic architecture of the human cerebral cortex
Katrina L. Grasby,Neda Jahanshad,Jodie N. Painter,Lucía Colodro-Conde,Janita Bralten,Derrek P. Hibar,Penelope A. Lind,Fabrizio Pizzagalli,Christopher R.K. Ching,Mary Agnes McMahon,Natalia Shatokhina,Leo Charles Peek Zsembik,Sophia I. Thomopoulos,Alyssa H. Zhu,Lachlan T. Strike,Ingrid Agartz,Saud Alhusaini,Marcio Almeida,Dag Alnæs,Inge K Amlien,Micael Andersson,Tyler Ard,Nicola J. Armstrong,Allison E. Ashley-Koch,Joshua R. Atkins,Manon Bernard,Rachel M. Brouwer,Elizabeth E.L. Buimer,Robin Bülow,Christian Bürger,Dara M. Cannon,M. Mallar Chakravarty,Qiang Chen,Joshua W. Cheung,Baptiste Couvy-Duchesne,Anders M. Dale,Shareefa Dalvie,Tânia Kawasaki de Araujo,Greig I. de Zubicaray,Sonja M C de Zwarte,Anouk den Braber,Nhat Trung Doan,Katharina Dohm,Stefan Ehrlich,Hannah-Ruth Engelbrecht,Susanne Erk,Chun Chieh Fan,Iryna O. Fedko,Sonya Foley,Judith M. Ford,Masaki Fukunaga,Melanie E. Garrett,Tian Ge,Sudheer Giddaluru,Aaron L. Goldman,Melissa J. Green,Nynke A. Groenewold,Dominik Grotegerd,Tiril P. Gurholt,Boris A. Gutman,Narelle K. Hansell,Mathew A. Harris,Marc B. Harrison,Courtney C. Haswell,Michael A. Hauser,Stefan Herms,Dirk J. Heslenfeld,New Fei Ho,D. Hoehn,Per Hoffmann,Laurena Holleran,Martine Hoogman,Jouke-Jan Hottenga,Masashi Ikeda,Deborah Janowitz,Iris E. Jansen,Tianye Jia,Christiane Jockwitz,Ryota Kanai,Sherif Karama,Dalia Kasperaviciute,Tobias Kaufmann,Sinead Kelly,Masataka Kikuchi,Marieke Klein,Michael Knapp,Annchen R. Knodt,Bernd Kramer,Max Lam,Thomas M. Lancaster,Phil Lee,Tristram A. Lett,Lindsay B. Lewis,Iscia Lopes-Cendes,Michelle Luciano,Fabio Macciardi,Andre F. Marquand,Samuel R. Mathias,Tracy R. Melzer,Yuri Milaneschi,Nazanin Mirza-Schreiber,José C. V. Moreira,Thomas W. Mühleisen,Bertram Müller-Myhsok,Pablo Najt,Soichiro Nakahara,Kwangsik Nho,Loes M. Olde Loohuis,Dimitri Papadopoulos Orfanos,John F. Pearson,Toni L. Pitcher,Benno Pütz,Yann Quidé,Anjanibhargavi Ragothaman,Faisal Rashid,William R. Reay,Ronny Redlich,Céline S. Reinbold,Jonathan Repple,Geneviève Richard,Brandalyn C. Riedel,Shannon L. Risacher,Cristiane S. Rocha,Nina Roth Mota,Lauren E. Salminen,Arvin Saremi,Andrew J. Saykin,Fenja Schlag,Lianne Schmaal,Peter R. Schofield,Rodrigo Secolin,Chin Yang Shapland,Li Shen,Jean Shin,Elena Shumskaya,Ida E Sønderby,Emma Sprooten,Katherine E. Tansey,Alexander Teumer,Anbupalam Thalamuthu,Diana Tordesillas-Gutiérrez,Jessica A. Turner,Anne Uhlmann,Costanza L. Vallerga,Dennis van der Meer,Marjolein M. J. Van Donkelaar,Liza van Eijk,Theo G.M. van Erp,Neeltje E.M. van Haren,Daan van Rooij,Marie-José van Tol,Jan H. Veldink,Ellen Verhoef,Esther Walton,Mingyuan Wang,Yunpeng Wang,Joanna M. Wardlaw,Wei Wen,Lars T. Westlye,Christopher D. Whelan,Stephanie H. Witt,Katharina Wittfeld,Christiane Wolf,Thomas Wolfers,Jing Qin Wu,Clarissa L. Yasuda,Dario Zaremba,Zuo Zhang,Marcel P. Zwiers,Eric Artiges,Amelia A. Assareh,Rosa Ayesa-Arriola,Aysenil Belger,Christine L. Brandt,Gregory G. Brown,Sven Cichon,Joanne E. Curran,Gareth E. Davies,Franziska Degenhardt,Michelle F. Dennis,Bruno Dietsche,Srdjan Djurovic,Colin P. Doherty,Ryan Espiritu,Daniel Garijo,Yolanda Gil,Penny A. Gowland,Robert C. Green,Alexander N. Häusler,Walter Heindel,Beng-Choon Ho,Wolfgang Hoffmann,Florian Holsboer,Georg Homuth,Norbert Hosten,Clifford R. Jack,MiHyun Jang,Andreas Jansen,Nathan A. Kimbrel,Knut K. Kolskår,Sanne Koops,Axel Krug,Kelvin O. Lim,Jurjen J. Luykx,Daniel H. Mathalon,Karen A. Mather,Venkata S. Mattay,Sarah Matthews,Jaqueline Mayoral Van Son,Sarah McEwen,Ingrid Melle,Derek W. Morris,Bryon A. Mueller,Matthias Nauck,Jan Egil Nordvik,Markus M. Nöthen,Daniel S. O'Leary,Nils Opel,Marie-Laure Paillère Martinot,G. Bruce Pike,Adrian Preda,Erin Burke Quinlan,Paul E. Rasser,Varun Ratnakar,Simone Reppermund,Vidar M. Steen,Paul A. Tooney,Fábio R. Torres,Dick J. Veltman,James T. Voyvodic,Robert Whelan,Tonya White,Hidenaga Yamamori,Hieab H.H. Adams,Joshua C. Bis,Stéphanie Debette,Charles DeCarli,Myriam Fornage,Vilmundur Gudnason,Edith Hofer,M. Arfan Ikram,Lenore J. Launer,William T. Longstreth,Oscar L. Lopez,Bernard Mazoyer,Thomas H. Mosley,Gennady V. Roshchupkin,Claudia L. Satizabal,Reinhold Schmidt,Sudha Seshadri,Qiong Yang,Marina K. M. Alvim,David Ames,Tim J. Anderson,Ole A. Andreassen,Alejandro Arias-Vasquez,Mark E. Bastin,Bernhard T. Baune,Jean C. Beckham,John Blangero,Dorret I. Boomsma,Henry Brodaty,Han G. Brunner,Randy L. Buckner,Jan K. Buitelaar,Juan R. Bustillo,Wiepke Cahn,Murray J. Cairns,Vince D. Calhoun,Vaughan J. Carr,Xavier Caseras,Svenja Caspers,Gianpiero L. Cavalleri,Fernando Cendes,Aiden Corvin,Benedicto Crespo-Facorro,John C. Dalrymple-Alford,Udo Dannlowski,Eco J. C. de Geus,Ian J. Deary,Norman Delanty,Chantal Depondt,Sylvane Desrivières,Gary Donohoe,Thomas Espeseth,Guillén Fernández,Simon E. Fisher,Herta Flor,Andreas J. Forstner,Clyde Francks,Barbara Franke,David C. Glahn,Randy L. Gollub,Hans J. Grabe,Oliver Gruber,Asta Håberg,Ahmad R. Hariri,Catharina A. Hartman,Ryota Hashimoto,Andreas Heinz,Frans Henskens,Manon H.J. Hillegers,Pieter J. Hoekstra,Avram J. Holmes,L. Elliot Hong,William D. Hopkins,Hilleke E. Hulshoff Pol,Terry L. Jernigan,Erik G. Jönsson,René S. Kahn,Martin A. Kennedy,Tilo Kircher,Peter Kochunov,John B.J. Kwok,Stephanie Le Hellard,Carmel M. Loughland,Nicholas G. Martin,Jean-Luc Martinot,Colm McDonald,Katie L. McMahon,Andreas Meyer-Lindenberg,Patricia T. Michie,Rajendra A. Morey,Bryan J. Mowry,Lars Nyberg,Jaap Oosterlaan,Roel A. Ophoff,Christos Pantelis,Tomáš Paus,Zdenka Pausova,Brenda W.J.H. Penninx,Tinca J. C. Polderman,Danielle Posthuma,Marcella Rietschel,Joshua L. Roffman,Laura M. Rowland,Perminder S. Sachdev,Philipp G. Sämann,Ulrich Schall,Gunter Schumann,Rodney J. Scott,Kang Sim,Sanjay M. Sisodiya,Jordan W. Smoller,Iris E. C. Sommer,Beate St Pourcain,Dan J. Stein,Arthur W. Toga,Julian N. Trollor,Nic J.A. van der Wee,Dennis van 't Ent,Henry Völzke,Henrik Walter,Bernd Weber,Daniel R. Weinberger,Margaret J. Wright,Juan Zhou,Jason L. Stein,Paul M. Thompson,Sarah E. Medland +359 more
TL;DR: Results support the radial unit hypothesis that different developmental mechanisms promote surface area expansion and increases in thickness and find evidence that brain structure is a key phenotype along the causal pathway that leads from genetic variation to differences in general cognitive function.
Journal ArticleDOI
Mechanisms and functions of lysosome positioning
TL;DR: This work reviews recent findings on the mechanisms that mediate the motility and positioning of lysosomes, and the importance ofLysosome dynamics for cell physiology and pathology.
Journal ArticleDOI
BORC/kinesin-1 Ensemble Drives Polarized Transport of Lysosomes Into the Axon
TL;DR: It is shown that an ensemble of BORC, Arl8, SKIP, and kinesin-1 specifically drives lysosome transport into the axon, and not the dendrites, in cultured rat hippocampal neurons, demonstrating that this transport is essential for maintenance of axonal growth-cone dynamics and autophagosome turnover.
Posted ContentDOI
The genetic architecture of the human cerebral cortex
Katrina L. Grasby,Neda Jahanshad,Jodie N. Painter,Lucía Colodro-Conde,Janita Bralten,Derrek P. Hibar,Derrek P. Hibar,Penelope A. Lind,Fabrizio Pizzagalli,Christopher R.K. Ching,Christopher R.K. Ching,Mary Agnes McMahon,Natalia Shatokhina,Leo Charles Peek Zsembik,Ingrid Agartz,Saud Alhusaini,Saud Alhusaini,Marcio Almeida,Dag Alnæs,Dag Alnæs,Inge K Amlien,Micael Andersson,Tyler Ard,Nicola J. Armstrong,Allison E. Ashley-Koch,Joshua R. Atkins,Manon Bernard,Rachel M. Brouwer,Elizabeth E.L. Buimer,Robin Bülow,Christian Bürger,Dara M. Cannon,M. Mallar Chakravarty,M. Mallar Chakravarty,Qiang Chen,Joshua W. Cheung,Baptiste Couvy-Duchesne,Baptiste Couvy-Duchesne,Anders M. Dale,Anders M. Dale,Shareefa Dalvie,Tânia Kawasaki de Araujo,Greig I. de Zubicaray,Sonja M C de Zwarte,Anouk den Braber,Nhat Trung Doan,Nhat Trung Doan,Katharina Dohm,Stefan Ehrlich,Hannah-Ruth Engelbrecht,Susanne Erk,Chun Chieh Fan,Iryna O. Fedko,Sonya Foley,Judith M. Ford,Masaki Fukunaga,Melanie E. Garrett,Tian Ge,Sudheer Giddaluru,Aaron L. Goldman,Melissa J. Green,Melissa J. Green,Nynke A. Groenewold,Dominik Grotegerd,Tiril P. Gurholt,Tiril P. Gurholt,Boris A. Gutman,Boris A. Gutman,Narelle K. Hansell,Mathew A. Harris,Marc B. Harrison,Courtney C. Haswell,Michael A. Hauser,Stefan Herms,Stefan Herms,Stefan Herms,Dirk J. Heslenfeld,New Fei Ho,D. Hoehn,Per Hoffmann,Per Hoffmann,Per Hoffmann,Laurena Holleran,Martine Hoogman,Jouke-Jan Hottenga,Masashi Ikeda,Deborah Janowitz,Iris E. Jansen,Tianye Jia,Tianye Jia,Christiane Jockwitz,Christiane Jockwitz,Ryota Kanai,Ryota Kanai,Sherif Karama,Sherif Karama,Sherif Karama,Dalia Kasperaviciute,Tobias Kaufmann,Tobias Kaufmann,Sinead Kelly,Sinead Kelly,Masataka Kikuchi,Marieke Klein,Marieke Klein,Michael Knapp,Annchen R. Knodt,Bernd Kramer,Bernd Kramer,Max Lam,Thomas M. Lancaster,Phil Lee,Tristram A. Lett,Lindsay B. Lewis,Lindsay B. Lewis,Iscia Lopes-Cendes,Michelle Luciano,Fabio Macciardi,Andre F. Marquand,Samuel R. Mathias,Tracy R. Melzer,Yuri Milaneschi,Nazanin Mirza-Schreiber,José C. V. Moreira,Thomas W. Mühleisen,Thomas W. Mühleisen,Thomas W. Mühleisen,Bertram Müller-Myhsok,Pablo Najt,Soichiro Nakahara,Soichiro Nakahara,Kwangsik Nho,Loes M. Olde Loohuis,Dimitri Papadopoulos Orfanos,John F. Pearson,Toni L. Pitcher,Benno Pütz,Yann Quidé,Yann Quidé,Anjanibhargavi Ragothaman,Faisal Rashid,William R. Reay,Ronny Redlich,Céline S. Reinbold,Céline S. Reinbold,Jonathan Repple,Geneviève Richard,Brandalyn C. Riedel,Brandalyn C. Riedel,Shannon L. Risacher,Cristiane S. Rocha,Nina Roth Mota,Lauren E. Salminen,Arvin Saremi,Andrew J. Saykin,Fenja Schlag,Lianne Schmaal,Lianne Schmaal,Peter R. Schofield,Peter R. Schofield,Rodrigo Secolin,Chin Yang Shapland,Li Shen,Jean Shin,Elena Shumskaya,Ida E Sønderby,Ida E Sønderby,Emma Sprooten,Lachlan T. Strike,Katherine E. Tansey,Alexander Teumer,Anbupalam Thalamuthu,Sophia I. Thomopoulos,Diana Tordesillas-Gutiérrez,Jessica A. Turner,Anne Uhlmann,Anne Uhlmann,Costanza L. Vallerga,Dennis van der Meer,Dennis van der Meer,Marjolein M. J. Van Donkelaar,Liza van Eijk,Theo G.M. van Erp,Neeltje E.M. van Haren,Neeltje E.M. van Haren,Daan van Rooij,Marie-José van Tol,Jan H. Veldink,Ellen Verhoef,Esther Walton,Esther Walton,Mingyuan Wang,Yunpeng Wang,Yunpeng Wang,Joanna M. Wardlaw,Wei Wen,Lars T. Westlye,Lars T. Westlye,Christopher D. Whelan,Christopher D. Whelan,Stephanie H. Witt,Katharina Wittfeld,Katharina Wittfeld,Christiane Wolf,Thomas Wolfers,Jing Qin Wu,Clarissa L. Yasuda,Dario Zaremba,Zuo Zhang,Alyssa H. Zhu,Marcel P. Zwiers,Eric Artiges,Amelia A. Assareh,Rosa Ayesa-Arriola,Aysenil Belger,Christine L. Brandt,Christine L. Brandt,Gregory G. Brown,Sven Cichon,Sven Cichon,Sven Cichon,Joanne E. Curran,Gareth E. Davies,Franziska Degenhardt,Michelle F. Dennis,Bruno Dietsche,Srdjan Djurovic,Srdjan Djurovic,Colin P. Doherty,Ryan Espiritu,Daniel Garijo,Yolanda Gil,Penny A. Gowland,Robert C. Green,Robert C. Green,Robert C. Green,Alexander N. Häusler,Alexander N. Häusler,Walter Heindel,Beng-Choon Ho,Wolfgang Hoffmann,Wolfgang Hoffmann,Florian Holsboer,Georg Homuth,Norbert Hosten,Clifford R. Jack,MiHyun Jang,Andreas Jansen,Nathan A. Kimbrel,Knut K. Kolskår,Sanne Koops,Axel Krug,Kelvin O. Lim,Jurjen J. Luykx,Daniel H. Mathalon,Daniel H. Mathalon,Karen A. Mather,Karen A. Mather,Venkata S. Mattay,Sarah Matthews,Jaqueline Mayoral Van Son,Sarah McEwen,Ingrid Melle,Ingrid Melle,Derek W. Morris,Bryon A. Mueller,Matthias Nauck,Jan Egil Nordvik,Markus M. Nöthen,Daniel S. O'Leary,Nils Opel,Marie-Laure Paillère Martinot,G. Bruce Pike,Adrian Preda,Erin Burke Quinlan,Paul E. Rasser,Varun Ratnakar,Simone Reppermund,Vidar M. Steen,Vidar M. Steen,Paul A. Tooney,Fábio R. Torres,Dick J. Veltman,James T. Voyvodic,Robert Whelan,Tonya White,Hidenaga Yamamori,Oscar L. Lopez,Hieab H.H. Adams,Joshua C. Bis,Stéphanie Debette,Charles DeCarli,Myriam Fornage,Vilmundur Gudnason,Edith Hofer,M. Arfan Ikram,Lenore J. Launer,William T. Longstreth,Bernard Mazoyer,Thomas H. Mosley,Gennady V. Roshchupkin,Claudia L. Satizabal,Claudia L. Satizabal,Reinhold Schmidt,Sudha Seshadri,Sudha Seshadri,Qiong Yang,Marina K. M. Alvim,David Ames,Tim J. Anderson,Ole A. Andreassen,Ole A. Andreassen,Alejandro Arias-Vasquez,Mark E. Bastin,Bernhard T. Baune,Bernhard T. Baune,John Blangero,Dorret I. Boomsma,Henry Brodaty,Han G. Brunner,Han G. Brunner,Randy L. Buckner,Jan K. Buitelaar,Juan R. Bustillo,Wiepke Cahn,Murray J. Cairns,Vince D. Calhoun,Vaughan J. Carr,Vaughan J. Carr,Vaughan J. Carr,Xavier Caseras,Svenja Caspers,Svenja Caspers,Gianpiero L. Cavalleri,Fernando Cendes,Benedicto Crespo-Facorro,John C. Dalrymple-Alford,Udo Dannlowski,Eco J. C. de Geus,Ian J. Deary,Chantal Depondt,Sylvane Desrivières,Gary Donohoe,Thomas Espeseth,Thomas Espeseth,Guillén Fernández,Simon E. Fisher,Simon E. Fisher,Herta Flor,Andreas J. Forstner,Clyde Francks,Clyde Francks,Barbara Franke,David C. Glahn,Randy L. Gollub,Hans J. Grabe,Hans J. Grabe,Oliver Gruber,Asta Håberg,Ahmad R. Hariri,Catharina A. Hartman,Ryota Hashimoto,Andreas Heinz,Frans Henskens,Manon H.J. Hillegers,Manon H.J. Hillegers,Pieter J. Hoekstra,Avram J. Holmes,Avram J. Holmes,L. Elliot Hong,William D. Hopkins,William D. Hopkins,Hilleke E. Hulshoff Pol,Terry L. Jernigan,Erik G. Jönsson,Erik G. Jönsson,René S. Kahn,René S. Kahn,Martin A. Kennedy,Tilo Kircher,Peter Kochunov,John B.J. Kwok,John B.J. Kwok,John B.J. Kwok,Stephanie Le Hellard,Stephanie Le Hellard,Carmel M. Loughland,Carmel M. Loughland,Nicholas G. Martin,Jean-Luc Martinot,Colm McDonald,Katie L. McMahon,Andreas Meyer-Lindenberg,Patricia T. Michie,Rajendra A. Morey,Bryan J. Mowry,Lars Nyberg,Jaap Oosterlaan,Jaap Oosterlaan,Roel A. Ophoff,Christos Pantelis,Tomáš Paus,Tomáš Paus,Zdenka Pausova,Brenda W.J.H. Penninx,Tinca J. C. Polderman,Danielle Posthuma,Marcella Rietschel,Joshua L. Roffman,Laura M. Rowland,Perminder S. Sachdev,Philipp G. Sämann,Ulrich Schall,Gunter Schumann,Rodney J. Scott,Rodney J. Scott,Kang Sim,Sanjay M. Sisodiya,Jordan W. Smoller,Jordan W. Smoller,Iris E. C. Sommer,Beate St Pourcain,Beate St Pourcain,Beate St Pourcain,Dan J. Stein,Arthur W. Toga,Julian N. Trollor,Nic J.A. van der Wee,Dennis van 't Ent,Henry Völzke,Henrik Walter,Bernd Weber,Bernd Weber,Daniel R. Weinberger,Margaret J. Wright,Juan Zhou,Jason L. Stein,Paul M. Thompson,Sarah E. Medland +438 more
TL;DR: A genome-wide association meta-analysis of brain MRI data from 35,660 individuals with replication in 15,578 individuals found significant enrichment for loci influencing total surface area within regulatory elements active during prenatal cortical development, supporting the radial unit hypothesis.
Journal ArticleDOI
Lysosome motility and distribution: Relevance in health and disease.
Juan Esteban Oyarzún,Jonathan Lagos,Mary Carmen Vázquez,Cristian Valls,Catalina De la Fuente,Maria-Isabel Yuseff,Alejandra R. Alvarez,Silvana Zanlungo +7 more
TL;DR: The correct localization of lysosomes is relevant in several physiological processes, including appropriate antigen presentation, neurotransmission and receptors modulation in neuronal synapsis, whereas hepatic lysOSomes and autophagy are master regulators of nutrient homeostasis.
References
More filters
Journal ArticleDOI
Haploview: analysis and visualization of LD and haplotype maps
TL;DR: Haploview is a software package that provides computation of linkage disequilibrium statistics and population haplotype patterns from primary genotype data in a visually appealing and interactive interface.
Journal ArticleDOI
Biological insights from 108 schizophrenia-associated genetic loci
Stephan Ripke,Stephan Ripke,Benjamin M. Neale,Benjamin M. Neale,Aiden Corvin,James T.R. Walters,Kai-How Farh,Peter Holmans,Phil Lee,Phil Lee,Brendan Bulik-Sullivan,Brendan Bulik-Sullivan,David A. Collier,David A. Collier,Hailiang Huang,Hailiang Huang,Tune H. Pers,Tune H. Pers,Tune H. Pers,Ingrid Agartz,Ingrid Agartz,Esben Agerbo,Esben Agerbo,Margot Albus,Madeline Alexander,Farooq Amin,Silviu Alin Bacanu,Martin Begemann,Richard A. Belliveau,Judit Bene,Sarah E. Bergen,Sarah E. Bergen,Elizabeth Bevilacqua,Tim B. Bigdeli,Donald W. Black,Richard Bruggeman,Nancy G. Buccola,Randy L. Buckner,William Byerley,Wiepke Cahn,Guiqing Cai,Dominique Campion,Rita M. Cantor,Vaughan J. Carr,Noa Carrera,Stanley V. Catts,Kimberly Chambert,Raymond C.K. Chan,Ronald Y.L. Chen,Eric Y.H. Chen,Wei Cheng,Eric F.C. Cheung,Siow Ann Chong,C. Robert Cloninger,David Cohen,Nadine Cohen,Paul Cormican,Nicholas John Craddock,James J. Crowley,David Curtis,David Curtis,Michael Davidson,Kenneth L. Davis,Franziska Degenhardt,Jurgen Del Favero,Ditte Demontis,Ditte Demontis,Dimitris Dikeos,Timothy G. Dinan,Srdjan Djurovic,Gary Donohoe,Gary Donohoe,Elodie Drapeau,Jubao Duan,Frank Dudbridge,Naser Durmishi,Peter Eichhammer,Johan G. Eriksson,Johan G. Eriksson,Valentina Escott-Price,Laurent Essioux,Ayman H. Fanous,Martilias S. Farrell,Josef Frank,Lude Franke,Robert Freedman,Nelson B. Freimer,Marion Friedl,Joseph I. Friedman,Menachem Fromer,Menachem Fromer,Menachem Fromer,Giulio Genovese,Lyudmila Georgieva,Ina Giegling,Ina Giegling,Paola Giusti-Rodríguez,Stephanie Godard,Jacqueline I. Goldstein,Jacqueline I. Goldstein,Vera Golimbet,Srihari Gopal,Jacob Gratten,Lieuwe de Haan,Christian Hammer,Marian L. Hamshere,Mark Hansen,Thomas Hansen,Vahram Haroutunian,Vahram Haroutunian,Annette M. Hartmann,Frans Henskens,Stefan Herms,Stefan Herms,Joel N. Hirschhorn,Joel N. Hirschhorn,Per Hoffmann,Per Hoffmann,A. Hofman,Mads V. Hollegaard,David M. Hougaard,Masashi Ikeda,Inge Joa,Antonio Julià,René S. Kahn,Luba Kalaydjieva,Sena Karachanak-Yankova,Juha Karjalainen,David J. Kavanagh,Matthew C. Keller,James L. Kennedy,Andrey Khrunin,Yunjung Kim,Janis Klovins,James A. Knowles,Bettina Konte,Vaidutis Kučinskas,Zita Ausrele Kucinskiene,Hana Kuzelova-Ptackova,Anna K. Kähler,Claudine Laurent,Jimmy Lee Chee Keong,S. Hong Lee,Sophie E. Legge,Bernard Lerer,Miaoxin Li,Tao Li,Kung-Yee Liang,Jeffrey A. Lieberman,Svetlana A. Limborska,Carmel M. Loughland,Jan Lubinski,Jouko Lönnqvist,Milan Macek,Patrik K. E. Magnusson,Brion S. Maher,Wolfgang Maier,J. Mallet,Sara Marsal,Manuel Mattheisen,Manuel Mattheisen,Manuel Mattheisen,Morten Mattingsdal,Robert W. McCarley,Colm McDonald,Andrew M. McIntosh,Sandra Meier,Carin J. Meijer,Béla Melegh,Ingrid Melle,Raquelle I. Mesholam-Gately,Andres Metspalu,Patricia T. Michie,Lili Milani,Vihra Milanova,Younes Mokrab,Derek W. Morris,Derek W. Morris,Ole Mors,Ole Mors,Kieran C. Murphy,Robin M. Murray,Inez Myin-Germeys,Bertram Mueller-Myhsok,Mari Nelis,Igor Nenadic,Deborah A. Nertney,Gerald Nestadt,Kristin K. Nicodemus,Liene Nikitina-Zake,Laura Nisenbaum,Annelie Nordin,Eadbhard O'Callaghan,Colm O'Dushlaine,F. Anthony O'Neill,Sang-Yun Oh,Ann Olincy,Line Olsen,Jim van Os,Jim van Os,Christos Pantelis,George N. Papadimitriou,Sergi Papiol,Elena Parkhomenko,Michele T. Pato,Tiina Paunio,Tiina Paunio,Milica Pejovic-Milovancevic,Diana O. Perkins,Olli Pietiläinen,Olli Pietiläinen,Jonathan Pimm,Andrew Pocklington,John Powell,Alkes L. Price,Alkes L. Price,Ann E. Pulver,Shaun Purcell,Digby Quested,Henrik B. Rasmussen,Abraham Reichenberg,Mark Reimers,Alexander Richards,Joshua L. Roffman,Panos Roussos,Douglas M. Ruderfer,Douglas M. Ruderfer,Veikko Salomaa,Alan R. Sanders,Ulrich Schall,Christian R. Schubert,Thomas G. Schulze,Thomas G. Schulze,Sibylle G. Schwab,Edward M. Scolnick,Rodney J. Scott,Larry J. Seidman,Jianxin Shi,Engilbert Sigurdsson,Teimuraz Silagadze,Jeremy M. Silverman,Jeremy M. Silverman,Kang Sim,Petr Slominsky,Jordan W. Smoller,Jordan W. Smoller,Hon-Cheong So,Chris C. A. Spencer,Eli A. Stahl,Eli A. Stahl,Hreinn Stefansson,Stacy Steinberg,Elisabeth Stögmann,Richard E. Straub,Eric Strengman,Jana Strohmaier,T. Scott Stroup,Mythily Subramaniam,Jaana Suvisaari,Dragan M. Svrakic,Jin P. Szatkiewicz,Erik Söderman,Srinivas Thirumalai,Draga Toncheva,Sarah Tosato,Juha Veijola,John L. Waddington,Dermot Walsh,Dai Wang,Qiang Wang,Bradley T. Webb,Mark Weiser,Dieter B. Wildenauer,Nigel Williams,Stephanie Williams,Stephanie H. Witt,Aaron R. Wolen,Emily H. M. Wong,Brandon Wormley,Hualin Simon Xi,Clement C. Zai,Xuebin Zheng,Fritz Zimprich,Naomi R. Wray,Kari Stefansson,Peter M. Visscher,Rolf Adolfsson,Ole A. Andreassen,Douglas Blackwood,Elvira Bramon,Joseph D. Buxbaum,Anders D. Børglum,Anders D. Børglum,Sven Cichon,Sven Cichon,Ariel Darvasi,Enrico Domenici,Hannelore Ehrenreich,Tõnu Esko,Tõnu Esko,Tõnu Esko,Pablo V. Gejman,Michael Gill,Hugh Gurling,Christina M. Hultman,Nakao Iwata,Assen Jablensky,Erik G. Jönsson,Erik G. Jönsson,Kenneth S. Kendler,George Kirov,Jo Knight,Todd Lencz,Todd Lencz,Douglas F. Levinson,Qingqin S. Li,Jianjun Liu,Jianjun Liu,Anil K. Malhotra,Anil K. Malhotra,Steven A. McCarroll,Steven A. McCarroll,Andrew McQuillin,Jennifer L. Moran,Preben Bo Mortensen,Preben Bo Mortensen,Bryan J. Mowry,Markus M. Noethen,Roel A. Ophoff,Roel A. Ophoff,Michael John Owen,Aarno Palotie,Aarno Palotie,Aarno Palotie,Carlos N. Pato,Tracey L. Petryshen,Tracey L. Petryshen,Danielle Posthuma,Danielle Posthuma,Marcella Rietschel,Brien P. Riley,Dan Rujescu,Dan Rujescu,Pak C. Sham,Pamela Sklar,David St Clair,Daniel R. Weinberger,Jens R. Wendland,Thomas Werge,Thomas Werge,Mark J. Daly,Mark J. Daly,Patrick F. Sullivan,Patrick F. Sullivan,Michael Conlon O'Donovan +354 more
TL;DR: Associations at DRD2 and several genes involved in glutamatergic neurotransmission highlight molecules of known and potential therapeutic relevance to schizophrenia, and are consistent with leading pathophysiological hypotheses.
Journal ArticleDOI
Implications of normal brain development for the pathogenesis of schizophrenia
TL;DR: The findings suggest that nonspecific histopathology exists in the limbic system, diencephalon, and prefrontal cortex, that the pathology occurs early in development, and that the causative process is inactive long before the diagnosis is made.
Journal ArticleDOI
The Wellcome Trust Case Control Consortium, U.K.
TL;DR: This article reports that the magazine's award for Research Leader of the Year was given to the Wellcome Trust Case Control Consortium which conducted a huge genetic study to look at the genetic causes for various diseases.
Journal ArticleDOI
Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis
Jordan W. Smoller,Kenneth S. Kendler,Nicholas John Craddock,Phil Lee,Benjamin M. Neale,John I. Nurnberger,Stephan Ripke,Susan L. Santangelo,Patrick F. Sullivan,Shaun Purcell,Richard Anney,Jan K. Buitelaar,Ayman H. Fanous,Stephen V. Faraone,Witte J.G. Hoogendijk,Klaus-Peter Lesch,Douglas F. Levinson,Roy H. Perlis,Marcella Rietschel,Brien P. Riley,Edmund J.S. Sonuga-Barke,Russell Schachar,Thomas G. Schulze,Anita Thapar,Michael C. Neale,Patrick Bender,Sven Cichon,Mark J. Daly,John R. Kelsoe,Thomas Lehner,Michael Conlon O'Donovan,Pablo V. Gejman,Jonathan Sebat,Pamela Sklar +33 more
TL;DR: The findings show that specific SNPs are associated with a range of psychiatric disorders of childhood onset or adult onset, and variation in calcium-channel activity genes seems to have pleiotropic effects on psychopathology.
Related Papers (5)
A human-specific AS3MT isoform and BORCS7 are molecular risk factors in the 10q24.32 schizophrenia - associated locus
Biological insights from 108 schizophrenia-associated genetic loci
Stephan Ripke,Stephan Ripke,Benjamin M. Neale,Benjamin M. Neale,Aiden Corvin,James T.R. Walters,Kai-How Farh,Peter Holmans,Phil Lee,Phil Lee,Brendan Bulik-Sullivan,Brendan Bulik-Sullivan,David A. Collier,David A. Collier,Hailiang Huang,Hailiang Huang,Tune H. Pers,Tune H. Pers,Tune H. Pers,Ingrid Agartz,Ingrid Agartz,Esben Agerbo,Esben Agerbo,Margot Albus,Madeline Alexander,Farooq Amin,Silviu Alin Bacanu,Martin Begemann,Richard A. Belliveau,Judit Bene,Sarah E. Bergen,Sarah E. Bergen,Elizabeth Bevilacqua,Tim B. Bigdeli,Donald W. Black,Richard Bruggeman,Nancy G. Buccola,Randy L. Buckner,William Byerley,Wiepke Cahn,Guiqing Cai,Dominique Campion,Rita M. Cantor,Vaughan J. Carr,Noa Carrera,Stanley V. Catts,Kimberly Chambert,Raymond C.K. Chan,Ronald Y.L. Chen,Eric Y.H. Chen,Wei Cheng,Eric F.C. Cheung,Siow Ann Chong,C. Robert Cloninger,David Cohen,Nadine Cohen,Paul Cormican,Nicholas John Craddock,James J. Crowley,David Curtis,David Curtis,Michael Davidson,Kenneth L. Davis,Franziska Degenhardt,Jurgen Del Favero,Ditte Demontis,Ditte Demontis,Dimitris Dikeos,Timothy G. Dinan,Srdjan Djurovic,Gary Donohoe,Gary Donohoe,Elodie Drapeau,Jubao Duan,Frank Dudbridge,Naser Durmishi,Peter Eichhammer,Johan G. Eriksson,Johan G. Eriksson,Valentina Escott-Price,Laurent Essioux,Ayman H. Fanous,Martilias S. Farrell,Josef Frank,Lude Franke,Robert Freedman,Nelson B. Freimer,Marion Friedl,Joseph I. Friedman,Menachem Fromer,Menachem Fromer,Menachem Fromer,Giulio Genovese,Lyudmila Georgieva,Ina Giegling,Ina Giegling,Paola Giusti-Rodríguez,Stephanie Godard,Jacqueline I. Goldstein,Jacqueline I. Goldstein,Vera Golimbet,Srihari Gopal,Jacob Gratten,Lieuwe de Haan,Christian Hammer,Marian L. Hamshere,Mark Hansen,Thomas Hansen,Vahram Haroutunian,Vahram Haroutunian,Annette M. Hartmann,Frans Henskens,Stefan Herms,Stefan Herms,Joel N. Hirschhorn,Joel N. Hirschhorn,Per Hoffmann,Per Hoffmann,A. Hofman,Mads V. Hollegaard,David M. Hougaard,Masashi Ikeda,Inge Joa,Antonio Julià,René S. Kahn,Luba Kalaydjieva,Sena Karachanak-Yankova,Juha Karjalainen,David J. Kavanagh,Matthew C. Keller,James L. Kennedy,Andrey Khrunin,Yunjung Kim,Janis Klovins,James A. Knowles,Bettina Konte,Vaidutis Kučinskas,Zita Ausrele Kucinskiene,Hana Kuzelova-Ptackova,Anna K. Kähler,Claudine Laurent,Jimmy Lee Chee Keong,S. Hong Lee,Sophie E. Legge,Bernard Lerer,Miaoxin Li,Tao Li,Kung-Yee Liang,Jeffrey A. Lieberman,Svetlana A. Limborska,Carmel M. Loughland,Jan Lubinski,Jouko Lönnqvist,Milan Macek,Patrik K. E. Magnusson,Brion S. Maher,Wolfgang Maier,J. Mallet,Sara Marsal,Manuel Mattheisen,Manuel Mattheisen,Manuel Mattheisen,Morten Mattingsdal,Robert W. McCarley,Colm McDonald,Andrew M. McIntosh,Sandra Meier,Carin J. Meijer,Béla Melegh,Ingrid Melle,Raquelle I. Mesholam-Gately,Andres Metspalu,Patricia T. Michie,Lili Milani,Vihra Milanova,Younes Mokrab,Derek W. Morris,Derek W. Morris,Ole Mors,Ole Mors,Kieran C. Murphy,Robin M. Murray,Inez Myin-Germeys,Bertram Mueller-Myhsok,Mari Nelis,Igor Nenadic,Deborah A. Nertney,Gerald Nestadt,Kristin K. Nicodemus,Liene Nikitina-Zake,Laura Nisenbaum,Annelie Nordin,Eadbhard O'Callaghan,Colm O'Dushlaine,F. Anthony O'Neill,Sang-Yun Oh,Ann Olincy,Line Olsen,Jim van Os,Jim van Os,Christos Pantelis,George N. Papadimitriou,Sergi Papiol,Elena Parkhomenko,Michele T. Pato,Tiina Paunio,Tiina Paunio,Milica Pejovic-Milovancevic,Diana O. Perkins,Olli Pietiläinen,Olli Pietiläinen,Jonathan Pimm,Andrew Pocklington,John Powell,Alkes L. Price,Alkes L. Price,Ann E. Pulver,Shaun Purcell,Digby Quested,Henrik B. Rasmussen,Abraham Reichenberg,Mark Reimers,Alexander Richards,Joshua L. Roffman,Panos Roussos,Douglas M. Ruderfer,Douglas M. Ruderfer,Veikko Salomaa,Alan R. Sanders,Ulrich Schall,Christian R. Schubert,Thomas G. Schulze,Thomas G. Schulze,Sibylle G. Schwab,Edward M. Scolnick,Rodney J. Scott,Larry J. Seidman,Jianxin Shi,Engilbert Sigurdsson,Teimuraz Silagadze,Jeremy M. Silverman,Jeremy M. Silverman,Kang Sim,Petr Slominsky,Jordan W. Smoller,Jordan W. Smoller,Hon-Cheong So,Chris C. A. Spencer,Eli A. Stahl,Eli A. Stahl,Hreinn Stefansson,Stacy Steinberg,Elisabeth Stögmann,Richard E. Straub,Eric Strengman,Jana Strohmaier,T. Scott Stroup,Mythily Subramaniam,Jaana Suvisaari,Dragan M. Svrakic,Jin P. Szatkiewicz,Erik Söderman,Srinivas Thirumalai,Draga Toncheva,Sarah Tosato,Juha Veijola,John L. Waddington,Dermot Walsh,Dai Wang,Qiang Wang,Bradley T. Webb,Mark Weiser,Dieter B. Wildenauer,Nigel Williams,Stephanie Williams,Stephanie H. Witt,Aaron R. Wolen,Emily H. M. Wong,Brandon Wormley,Hualin Simon Xi,Clement C. Zai,Xuebin Zheng,Fritz Zimprich,Naomi R. Wray,Kari Stefansson,Peter M. Visscher,Rolf Adolfsson,Ole A. Andreassen,Douglas Blackwood,Elvira Bramon,Joseph D. Buxbaum,Anders D. Børglum,Anders D. Børglum,Sven Cichon,Sven Cichon,Ariel Darvasi,Enrico Domenici,Hannelore Ehrenreich,Tõnu Esko,Tõnu Esko,Tõnu Esko,Pablo V. Gejman,Michael Gill,Hugh Gurling,Christina M. Hultman,Nakao Iwata,Assen Jablensky,Erik G. Jönsson,Erik G. Jönsson,Kenneth S. Kendler,George Kirov,Jo Knight,Todd Lencz,Todd Lencz,Douglas F. Levinson,Qingqin S. Li,Jianjun Liu,Jianjun Liu,Anil K. Malhotra,Anil K. Malhotra,Steven A. McCarroll,Steven A. McCarroll,Andrew McQuillin,Jennifer L. Moran,Preben Bo Mortensen,Preben Bo Mortensen,Bryan J. Mowry,Markus M. Noethen,Roel A. Ophoff,Roel A. Ophoff,Michael John Owen,Aarno Palotie,Aarno Palotie,Aarno Palotie,Carlos N. Pato,Tracey L. Petryshen,Tracey L. Petryshen,Danielle Posthuma,Danielle Posthuma,Marcella Rietschel,Brien P. Riley,Dan Rujescu,Dan Rujescu,Pak C. Sham,Pamela Sklar,David St Clair,Daniel R. Weinberger,Jens R. Wendland,Thomas Werge,Thomas Werge,Mark J. Daly,Mark J. Daly,Patrick F. Sullivan,Patrick F. Sullivan,Michael Conlon O'Donovan +354 more
Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis
Jordan W. Smoller,Kenneth S. Kendler,Nicholas John Craddock,Phil Lee,Benjamin M. Neale,John I. Nurnberger,Stephan Ripke,Susan L. Santangelo,Patrick F. Sullivan,Shaun Purcell,Richard Anney,Jan K. Buitelaar,Ayman H. Fanous,Stephen V. Faraone,Witte J.G. Hoogendijk,Klaus-Peter Lesch,Douglas F. Levinson,Roy H. Perlis,Marcella Rietschel,Brien P. Riley,Edmund J.S. Sonuga-Barke,Russell Schachar,Thomas G. Schulze,Anita Thapar,Michael C. Neale,Patrick Bender,Sven Cichon,Mark J. Daly,John R. Kelsoe,Thomas Lehner,Michael Conlon O'Donovan,Pablo V. Gejman,Jonathan Sebat,Pamela Sklar +33 more