Eva Loth

TL;DR: The ENIGMA Consortium has detected factors that affect the brain that no individual site could detect on its own, and that require larger numbers of subjects than any individual neuroimaging study has currently collected.

TL;DR: In this article, the authors report genome-wide association meta-analyses and replication for mean bilateral hippocampal, total brain and intracranial volumes from a large multinational consortium.

TL;DR: The strategies the IMAGEN consortium used to meet the challenges posed by large-scale multicentre imaging–genomics investigations are described, including standardization of the clinical, psychometric and neuroimaging-acquisition protocols, development of a central database for efficient analyses of large multimodal data sets and new analytic approaches to large- scale genetic neuroim imaging analyses.

TL;DR: The results indicate that both neural endophenotypes and genetic variation give rise to the various manifestations of impulsive behavior.

TL;DR: FXS is at the forefront of efforts to develop drugs for neurodevelopmental disorders, and lessons learned in the process will also be important for such disorders.