R
Roger White
Researcher at Imperial College London
Publications - 71
Citations - 10429
Roger White is an academic researcher from Imperial College London. The author has contributed to research in topics: Nuclear receptor & Receptor. The author has an hindex of 40, co-authored 70 publications receiving 10158 citations. Previous affiliations of Roger White include New York University & Lincoln's Inn.
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Journal ArticleDOI
Cognitive impairments in adult mice with constitutive inactivation of RIP140 gene expression.
Florian Duclot,Marion Lapierre,Marion Lapierre,Samuel Fritsch,Samuel Fritsch,Roger White,Malcolm G. Parker,Tangui Maurice,Tangui Maurice,Vincent Cavaillès,Vincent Cavaillès +10 more
TL;DR: Observations showed that RIP140 gene depletion results in learning and memory deficits as well as stress response, bringing to light a major role for this transcriptional coregulator in the neurophysiological developmental mechanisms underlying cognitive functions.
Journal ArticleDOI
1,4-Bis[2-(3,5-dichloropyridyloxy)]benzene, an extremely potent modulator of mouse hepatic cytochrome P-450 gene expression.
TL;DR: The findings demonstrate that TCPOBOP is one of the most potent modulators of cytochrome P-450 gene expression described to date, and it is not inconceivable that a single dose of this compound may alter hepatic gene expression for the majority of the lifespan of a mouse.
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Identification of phosphorylation sites in the mouse oestrogen receptor
TL;DR: A region of AF-1 that encompasses Ser-122 appears to interact with AF-2 in the full-length receptor, and a reduction of transcriptional activity was observed when Ser- 122 was mutated in the context of mutations in a putative amphipathic alpha-helix involved in AF- 2 activity.
Journal ArticleDOI
Multiple signaling defects in the absence of RIP140 impair both cumulus expansion and follicle rupture.
Jennifer M. A. Tullet,Victoria Pocock,Jennifer H. Steel,Roger White,Stuart Milligan,Malcolm G. Parker +5 more
TL;DR: It is proposed that widespread gene dysregulation in ovarian tissues in the absence of RIP140 leads to the anovulatory phenotype, and an important role for RIP140 in the regulation of multiple processes leading to ovulation is defined.
Journal ArticleDOI
Elevated expression of the metabolic regulator receptor-interacting protein 140 results in cardiac hypertrophy and impaired cardiac function
Asmaà Fritah,Jennifer H. Steel,Donna Nichol,Nadeene Parker,Sharron Williams,Anthony N. Price,Leena Strauss,Timothy A. Ryder,Margaret A. Mobberley,Matti Poutanen,Malcolm G. Parker,Roger White +11 more
TL;DR: This study demonstrates that RIP140 is an important cofactor in postnatal cardiac function and that inhibition of the action of RIP140 may provide a model system to investigate specific interventions designed to prevent or delay the onset of cardiac disease.