Roland Berger

TL;DR: In this paper, the authors used morphologic, cytogenetic, and molecular analyses for optimal management of acute promyelocytic leukemia (APL) patients and better understanding of the pathogenesis of the disease.

TL;DR: It is shown that the BCMA gene is organized into three exons and its major initiation transcription site is located 69 nucleotides downstream of a TATA box, suggesting a role for this gene in the B-cell developmental process.

TL;DR: This retrospective study reviewed 94 patients with thrombocythemia, finding that therapeutic measures must be conservative: anti‐aggregating drugs in small doses, and chemotherapy beginning with nonalkylating agents, are needed.

TL;DR: The fact that P53 gene mutations occurred more often in patients with 17p monosomy seems to support the "recessive" model of tumor suppressive activity of the P53 genes rather than the "dominant" model, in which alteration of only one allele is sufficient for the development of malignancy.

TL;DR: The fusion of the Huntingtin interactin protein 1 (HIP1) gene to the platelet-derived growth factor betareceptor (PDGF betaR) gene in a patient with chronic myelomonocytic leukemia is reported, consistent with an alternative mechanism for activation of PDGFbetaR tyrosine kinase activity by fusion with HIP1, leading to transformation of hematopoietic cells.