G
Gérard Tobelem
Researcher at French Institute of Health and Medical Research
Publications - 118
Citations - 6004
Gérard Tobelem is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: Endothelial stem cell & Platelet. The author has an hindex of 44, co-authored 118 publications receiving 5831 citations. Previous affiliations of Gérard Tobelem include University of Paris & Paris Diderot University.
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Further pharmacological and genetic evidence for the efficacy of PlGF inhibition in cancer and eye disease.
Sara Van de Veire,Ingeborg Stalmans,Femke Heindryckx,Hajimu Oura,Annemilaï Tijeras-Raballand,Thomas Schmidt,Sonja Loges,Imke Albrecht,Bart Jonckx,Stefan Vinckier,Christophe Van Steenkiste,Sonia Tugues,Sonia Tugues,Charlotte Rolny,Maria De Mol,Daniela Dettori,Patricia Hainaud,Lieve Coenegrachts,Jean Olivier Contreres,Tine Van Bergen,Henar Cuervo,Wei Hong Xiao,Carole Le Henaff,Ian Buysschaert,Behzad Kharabi Masouleh,Anja Geerts,Tibor Schomber,Philippe Bonnin,Vincent Lambert,Jurgen Haustraete,Serena Zacchigna,Jean-Marie Rakic,Wladimiro Jiménez,Agnès Noël,Mauro Giacca,Isabelle Colle,Jean-Michel Foidart,Gérard Tobelem,Manuel Morales-Ruiz,José Vilar,Patrick H. Maxwell,Stanley A. Vinores,Stanley A. Vinores,Geert Carmeliet,Mieke Dewerchin,Lena Claesson-Welsh,Evelyne Dupuy,Hans Van Vlierberghe,Gerhard Christofori,Massimiliano Mazzone,Michael Detmar,Desire Collen,Peter Carmeliet +52 more
TL;DR: It is shown that PlGF blockage inhibits vessel abnormalization rather than density in certain tumors while enhancing VEGF-targeted inhibition in ocular disease and warrant further testing of anti-PlGF therapies.
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Essential thrombocythemias: clinical evolutionary and biological data
Sylvia Bellucci,Maud Janvier,Gérard Tobelem,Georges Flandrin,Yves Charpak,Roland Berger,Michel Boiron +6 more
TL;DR: This retrospective study reviewed 94 patients with thrombocythemia, finding that therapeutic measures must be conservative: anti‐aggregating drugs in small doses, and chemotherapy beginning with nonalkylating agents, are needed.
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The Role of the Vascular Endothelial Growth Factor–Delta-like 4 Ligand/Notch4-Ephrin B2 Cascade in Tumor Vessel Remodeling and Endothelial Cell Functions
Patricia Hainaud,Jean-Olivier Contreres,Aude Villemain,Lang-Xia Liu,Jean Plouët,Gérard Tobelem,Evelyne Dupuy +6 more
TL;DR: This study strongly suggests that a coordinated activation of DDL4/Notch4 and ephrin B2 pathways downstream of VEGF plays a key role in the abnormal remodeling of tumor vessels.
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Binding and endocytosis of heparin by human endothelial cells in culture
TL;DR: The results suggest that a fraction of bound heparin is internalized by the vascular endothelium, and was not available to degradation by purified microbial Heparinase.
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Autoantibodies against Erythropoietin in a Patient with Pure Red-Cell Aplasia
Nicole Casadevall,Evelyne Dupuy,Pascale Molho-Sabatier,Gérard Tobelem,Bruno Varet,Patrick Mayeux +5 more
TL;DR: Patients with pure red-cell aplasia have thymomas, and remission of the anemia occurs in 25 to 30 percent of these patients after the thymoma is removed and a good response to plasmapheresis has been reported in two patients.